Background: Polypharmacy is a common practice in schizophrenia. Consequently, therapeutic drug monitoring is usually adopted to maintain the concentrations of the drugs in the plasma within a targeted therapeutic range, to maximize therapeutic efficiency and to diminish adverse side effects.
Methodology: This study reports on a column switching UHPLC-MS/MS method to determine psychotropic drugs in plasma samples simultaneously.
Results: The method was linear from 0.025 to 1.25 ng ml with R above 0.9950 and the lack of fit test (p > 0.05). The precision values presented coefficients of variation lower than 12%, and the relative standard error of the accuracy were lower than 14%.
Conclusion: The column switching UHPLC-MS/MS method developed herein successfully determined drugs in schizophrenic patients' plasma samples for therapeutic drug monitoring.
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| http://dx.doi.org/10.4155/bio-2016-0301 | DOI Listing |
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