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Symmetrical Drug-Related Intertriginous and Flexural Exanthema With Amoxicillin: Presenting a Flare-Up Phenomenon.
Cureus
November 2024
Allergy Department, Hospital General Universitario Gregorio Marañón, Madrid, ESP.
This case report describes a 40-year-old male patient who developed symmetrical drug-related intertriginous and flexural exanthema after taking amoxicillin. Initial allergy testing showed negative intradermal tests, but subsequent drug provocation tests with amoxicillin and penicillin were positive, indicating cross-reactivity between these β-lactam antibiotics. Notably, following the final provocation test, the intradermal test with penicillin turned positive, demonstrating a flare-up phenomenon.
View Article and Find Full Text PDFBullous Symmetric Drug-Related Intertriginous and Flexural Exanthem Secondary to Trimethoprim/Sulfamethoxazole.
Cureus
November 2024
Department of Dermatology, University of Florida College of Medicine, Gainesville, USA.
Symmetric drug-related intertriginous and flexural exanthem (SDRIFE) is a rare delayed-type hypersensitivity reaction that is considered a variant of systemic allergic contact dermatitis. It is typically triggered by drugs such as beta-lactam antibiotics or antihypertensives. The reaction presents as erythema with flexural prominence.
View Article and Find Full Text PDFA rare long-term side effect of COVID-19 vaccines: Symmetrical drug-related intertriginous and flexural exanthema-like reaction SDRIFE and potential immunogens for delayed type hypersensitivity reactions.
Int Immunopharmacol
January 2025
Ege University, Faculty of Medicine, Department of Pulmonary Medicine, Immunology and Allergy, Laboratory of Occupational/Environmental Respiratory Diseases and Asthma, 35100 Izmir, Türkiye; EgeSAM (Ege University Translational Pulmonary Research Center), 35100 Izmir, Türkiye. Electronic address:
Background: Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) is an important clinical entity that is rare and may develop with a Type IV delayed type hypersensitivity immune response to drug antigens. The incidence and characteristics of SDRIFE attributed to COronaVIrus Disease of 2019 (COVID-19) vaccines remain unclear, this issue requires further elucidation.
Objective: We aim to investigate the vaccine-related-SDRIFE and potential immunogens of COVID-19 vaccines through a literature review accompanied by a real case.
Symmetrical Drug-Related Intertriginous and Flexural Exanthema: A Probable Association to Siddha Medication Presenting as Baboon Syndrome.
Indian Dermatol Online J
July 2024
Department of Dermatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Rivaroxaban-Induced Symmetrical Drug-Related Intertriginous and Flexural Exanthema.
Dermatitis
October 2024
Allergy and Clinical Immunology Department, Coimbra University Hospital Center, Coimbra, Portugal.
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