https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=28221114&retmode=xml&tool=Litmetric&email=readroberts32@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09 282211142018020920181113
1080-60592332017MarEmerging infectious diseasesEmerg Infect DisMycobacterium tuberculosis Infection in Free-Roaming Wild Asian Elephant.555557555-55710.3201/eid2303.161439Postmortem examination of a wild Asian elephant at Rajiv Gandhi National Park, India, revealed nodular lesions, granulomas with central caseation, and acid-fast bacilli in the lungs. PCR and nucleotide sequencing confirmed the presence of Mycobacterium tuberculosis. This study indicates that wild elephants can harbor M. tuberculosis that can become fatal.ChandranaikBasavegowdanadoddi MarinaikBMShivashankarBeechagondahalli PapannaBPUmashankarKunigal SrinivasaKSNandiniPoojappaPGiridharPapannaPByregowdaSomenahalli MunivenkatappaSMShrinivasaBasavegowdanadoddi MarinaikBMengCase ReportsJournal Article
United StatesEmerg Infect Dis95081551080-6040IMAnimalsAnimals, WildElephantsmicrobiologyIndiaepidemiologyMycobacterium tuberculosisgeneticsisolation & purificationPhylogenyTuberculosis, PulmonaryepidemiologymicrobiologyveterinaryAsian elephantElephas maximusIndiaMycobacteriumbacteriatuberculosis and other mycobacteriazoonoses
201722260201722260201821060201731ppublish28221114PMC538275610.3201/eid2303.161439World Health Organization, Regional Office for South-East Asia. Tuberculosis control in the South-East Asia Region: annual report, 2015. [cited 2016 Jul 14].http://www.searo.who.int/tb/annual-tb-report-2015.pdfAlexander KA, Pleydell E, Williams MC, Lane EP, Nyange JFC, Michel AL. Mycobacterium tuberculosis: an emerging disease of free-ranging wildlife. Emerg Infect Dis. 2002;8:598–601. 10.3201/eid0806.01035810.3201/eid0806.010358PMC273849612023916Montali RJ, Mikota SK, Cheng LI. Mycobacterium tuberculosis in zoo and wildlife species. Rev Sci Tech. 2001;20:291–303. 10.20506/rst.20.1.126810.20506/rst.20.1.126811288517Oh P, Granich R, Scott J, Sun B, Joseph M, Stringfield C, et al. Human exposure following Mycobacterium tuberculosis infection of multiple animal species in a Metropolitan Zoo. Emerg Infect Dis. 2002;8:1290–3. 10.3201/eid0811.02030210.3201/eid0811.020302PMC273853912453358Obanda V, Poghon J, Yongo M, Mulei I, Ngotho M, Waititu K, et al. First reported case of fatal tuberculosis in a wild African elephant with past human-wildlife contact. Epidemiol Infect. 2013;141:1476–80. 10.1017/S095026881300002210.1017/S0950268813000022PMC915528723340041Perera BVP, Salgadu MA, Gunawardena GSPS, Smith NH, Jinadasa HRN. First confirmed case of fatal tuberculosis in a wild Sri Lankan elephant. Gajah. 2014;41:28–31.Alex K, Verma R. PCR-SSCCP analysis in detecting point mutations targeting rpoB, katG and inhA genes for determining multi-drug resistance in Mycobacterium bovis and Mycobacterium tuberculosis strains. Indian J Anim Sci. 2014;84:1256–60.Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol. 2013;30:2725–9. 10.1093/molbev/mst19710.1093/molbev/mst197PMC384031224132122Rishikesavan R, Chandranaik BM, Swathi B, Roopa S, Giridhar P, Renukaprasad C. Pathoepidemiological study of tuberculosis in Panthera pardus. Zoos Print J. 2010;25:28–9.Morse SS. Factors in the emergence of infectious diseases. Emerg Infect Dis. 1995;1:7–15. 10.3201/eid0101.95010210.3201/eid0101.950102PMC26268288903148