AI Article Synopsis
- The decaheme cytochrome MtrC from Shewanella oneidensis MR-1, when immobilized on an ITO electrode, shows exceptional hydrogen peroxide (HO) reduction abilities.
- Although MtrC has lower peroxidase activity in solution than traditional horseradish peroxidase, its ten heme cofactors provide excellent electronic communication, leading to increased efficiency on the electrode surface.
- Studies indicate that a high valent iron-oxo species acts as a key catalytic intermediate, positioning MtrC as a promising candidate for applications in fuel cells and biosensors.
Article Abstract
The decaheme cytochrome MtrC from Shewanella oneidensis MR-1 immobilized on an ITO electrode displays unprecedented HO reduction activity. Although MtrC showed lower peroxidase activity in solution compared to horseradish peroxidase, the ten heme cofactors enable excellent electronic communication and a superior activity on the electrode surface. A hierarchical ITO electrode enabled optimal immobilization of MtrC and a high current density of 1 mA cm at 0.4 V vs SHE could be obtained at pH 6.5 (E = 0.72 V). UV-visible and Resonance Raman spectroelectrochemical studies suggest the formation of a high valent iron-oxo species as the catalytic intermediate. Our findings demonstrate the potential of multiheme cytochromes to catalyze technologically relevant reactions and establish MtrC as a new benchmark in biotechnological HO reduction with scope for applications in fuel cells and biosensors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411108 | PMC |
| http://dx.doi.org/10.1021/jacs.6b12437 | DOI Listing |
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