Twenty five patients of viral warts were tested with various antigens of secondary,(recall antigens), primary delayed (DNCB) and inflammatory (croton oil) type. Significantly depresed responses were elicited with various antigens in patients with warts as compared to controls.
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J Med Virol
January 2025
Sao Carlos Institute of Physics, University of Sao Paulo, Sao Paulo, Brazil.
Human papillomavirus (HPV) infections rank as the most prevalent sexually transmitted infections globally. The Brazilian Ministry of Health recommends the topical use of 70%-90% trichloroacetic acid (TAA) for treating condyloma acuminata, yet this method suffers from a high recurrence rate of 36% and requires roughly six applications. Topical photodynamic therapy (PDT) has shown effectiveness in targeting subclinical lesions, but it also necessitates multiple sessions for complete lesion clearance.
View Article and Find Full Text PDFAm J Transl Res
December 2024
Department of Dermatology, Qingpu Branch of Zhongshan Hospital, Fudan University Shanghai, China.
Objective: To analyze the clinical application value of CO laser combined with 5-aminolevulinic acid photodynamic therapy for periungual and plantar warts.
Methods: Data from patients with periungual and plantar warts treated at Qingpu branch of Zhongshan Hospital, Fudan University between August 2022 and January 2024 were retrospectively analyzed. After screening based on inclusion and exclusion criteria, 96 patients were included and categorized into two groups according to their treatment regimens: a combination group (n=50, receiving CO laser therapy and 5-aminolevulinic acid photodynamic therapy) and a control group (n=46, undergoing CO laser treatment alone).
Clin Exp Dermatol
January 2025
Inonu University, Department of Dermatology, Malatya, Turkey.
PLoS Pathog
January 2025
Department of Pathology, Johns Hopkins University, Baltimore, Maryland, United States of America.
Typical epidermodysplasia verruciformis (EV) is a rare, autosomal recessive disorder characterized by an unusual susceptibility to infection with specific skin-trophic types of human papillomavirus, principally betapapillomaviruses, and a propensity for developing malignant skin tumors in sun exposed regions. Its etiology reflects biallelic loss-of-function mutations in TMC6 (EVER1), TMC8 (EVER2) or CIB1. A TMC6-TMC8-CIB1 protein complex in the endoplasmic reticulum is hypothesized to be a restriction factor in keratinocytes for βHPV infection.
View Article and Find Full Text PDFArch Dermatol Res
January 2025
College of Pharmacy, Al-Mustaqbal University, 51001, Hillah, Babylon, Iraq.
Management of plane warts is difficult; techniques like cryotherapy and cauterization are linked with a significant number of recurrences, risk of scarring, pain, and costs. To evaluate the effectiveness of TCA 30% solution in comparison with tretinoin 0.05% cream and5-flurouracil (5-FU) 5% cream in treatment of plane wart.
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