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Successful use of sirolimus for refractory atrial ectopic tachycardia in a child with cardiac rhabdomyoma. | LitMetric

AI Article Synopsis

  • Cardiac rhabdomyomas are frequently found in patients with tuberous sclerosis, a genetic disorder.
  • A case is presented where a child experienced arrhythmia due to rhabdomyoma that did not respond to standard antiarrhythmic medications.
  • The arrhythmia was successfully treated with the mTOR inhibitor sirolimus, marking the first known use of this drug for this type of condition.

Article Abstract

Cardiac rhabdomyomas are common in tuberous sclerosis. We report a child who developed rhabdomyoma related arrhythmia refractory to antiarrhythmic drug therapy. Reversion of the atrial ectopic tachycardia was achieved with mammalian target of rapamycin pathway (mTOR) inhibitor sirolimus. As per our knowledge, this is the first time that sirolimus has been successfully used in this setting.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931800PMC
http://dx.doi.org/10.1111/anec.12435DOI Listing

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