AI Article Synopsis
- A new method for [4+3] cycloaddition using ortho-hydroxybenzyl alcohols and N,N'-cyclic azomethine imines has been developed with Brønsted acid catalysis.
- This technique successfully produces valuable seven-membered heterocyclic compounds.
- The results show high efficiency with yields reaching up to 92% and excellent diastereoselectivity, often exceeding a 95:5 ratio.
Article Abstract
The first [4+3] cycloaddition of ortho-hydroxybenzyl alcohols has been established by making use of N,N'-cyclic azomethine imines as suitable 1,3-dipoles under Brønsted acid catalysis. By using this strategy, biologically important seven-membered heterocyclic scaffolds have been constructed in good yields and excellent diastereoselectivities (up to 92% yield, most >95 : 5 dr).
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| http://dx.doi.org/10.1039/c6cc09775h | DOI Listing |
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