Objectives: The aim of the present work was to synthesize a novel series of pyrazolo[3,4-]pyrimidin-4(5)-one derivatives and evaluate their antimicrobial activity.
Methods: Cyclization of an ortho-amino ester of 1-(2,4-dinitrophenyl)pyrazole with various aliphatic/aromatic nitriles under different reaction conditions such as conventional and microwave assisted synthesis, provided pyrazolo[3,4-] pyrimidin-4(5)-one derivatives. All the synthesized compounds were evaluated for their antimicrobial activity against selected bacteria and fungi by agar well diffusion method.
Results: All newly synthesized compounds were characterized using spectral and elemental analysis. Compounds 2e, 2f, and 2g showed significant antimicrobial activity as compared to standard drugs used.
Conclusion: The newly synthesized compounds could be useful templates for the design and optimization of more active analogs as a possible antimicrobial agent.
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| http://dx.doi.org/10.4103/0975-7406.199337 | DOI Listing |
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