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Unraveling the Molecular Architecture of Mosquito D1-Like Dopamine Receptors: Insights Into Ligand Binding and Structural Dynamics for Insecticide Development.
Proteins
January 2025
Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.
Vector-borne diseases pose a severe threat to human life, contributing significantly to global mortality. Understanding the structure-function relationship of the vector proteins is pivotal for effective insecticide development due to their involvement in drug resistance and disease transmission. This study reports the structural and dynamic features of D1-like dopamine receptors (DARs) in disease-causing mosquito species, such as Aedes aegypti, Culex quinquefasciatus, Anopheles gambiae, and Anopheles stephensi.
View Article and Find Full Text PDFSynthesis, and Insecticidal Activities of Propargyloxy-Diphenyl Oxide-Sulfonamide Derivatives.
Chem Biodivers
April 2024
College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Agricultural pests are the primary contributing factor to crop yield reduction, particularly in underdeveloped regions. Despite the significant efficacy of pesticides in pest control, their extensive use has led to the drug-fast of insecticide resistance. Developing of new environmentally friendly plant-based pesticides is an urgent necessity.
View Article and Find Full Text PDFInsect cuticle and insecticide development.
Arch Insect Biochem Physiol
December 2023
School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.
Insecticide resistance poses a significant challenge, diminishing the effectiveness of chemical insecticides. To address this global concern, the development of novel and efficient pest management technologies based on chemical insecticides is an ongoing necessity. The insect cuticle, a highly complex and continuously renewing organ, plays a crucial role in this context.
View Article and Find Full Text PDFThe recent developments of camptothecin and its derivatives as potential anti-tumor agents.
Eur J Med Chem
November 2023
School of Pharmacy, Yantai University, Yantai, 264005, China. Electronic address:
This review article focuses on the research progress made in the structural modifications of camptothecin (CPT), a potent cytotoxic natural alkaloid. CPT possesses a unique 5-fused ring structure and exhibits various beneficial activities such as anti-proliferative, anti-fungal, insecticidal, and anti-SARS-CoV-2 properties. CPT and its analogs, including Topotecan and Irinotecan, have been successfully developed and marketed as topoisomerase I inhibitors.
View Article and Find Full Text PDFVenom composition and bioactive RF-amide peptide toxins of the saddleback caterpillar, Acharia stimulea (Lepidoptera: Limacodidae).
Biochem Pharmacol
July 2023
Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia; Australian Research Council Centre of Excellence for Innovations in Protein and Peptide Science, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia. Electronic address:
Limacodidae is a family of lepidopteran insects comprising >1500 species. More than half of these species produce pain-inducing defensive venoms in the larval stage, but little is known about their venom toxins. Recently, we characterised proteinaceous toxins from the Australian limacodid caterpillar Doratifera vulnerans, but it is unknown if the venom of this species is typical of other Limacodidae.
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