AI Article Synopsis
- Urinary dysfunction (UD) is a prevalent issue in patients with Parkinson's disease (PD), linked to neurodegeneration in brain areas related to cognitive function.
- Over half (55.3%) of PD patients in a study reported experiencing UD, with those affected showing poorer performance in global cognition, visuo-constructive skills, and daily living activities compared to those without UD.
- Patients requiring medication for UD exhibited even greater cognitive impairments, indicating that cognitive decline and urinary issues in PD may be connected regardless of treatment effects.
Article Abstract
Urinary dysfunction (UD) is a common non-motor feature of Parkinson's disease (PD), and might be secondary to neurodegeneration involving cortical and subcortical brain areas. The possible link between UD and cognitive deficits has never been examined in frontal cortex impairment, and is still not completely understood in PD. In the present study, 94 PD patients underwent a comprehensive motor, cognitive and non-motor assessment. It was shown that 55.3% of patients reported UD, of which 17% needed specific urological treatment. Patients who reported UD performed worse on global cognition (PANDA, p = .05), visuo-constructive functions (CERAD/praxis, p = .03; and Figure Test, p = .03), and instrumental activities of daily living functions (IADL, p = .03), than patients without UD. The group with UD medication performed worse on global cognition (PANDA, p = .02) and visuo-constructive functions (CERAD/praxis, p = .05; CERAD/praxis recall, p = .05) than the UD group without medication, independent of anticholinergic treatment effect. Our findings suggest an association between cognitive impairment and UD in PD independent from symptomatic treatment.
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| http://dx.doi.org/10.1007/s00702-017-1690-2 | DOI Listing |
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