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Developmental dynamics mimicking inversely engineered pericellular matrix for articular cartilage regeneration.
Biomaterials
December 2024
School of Medicine, Nankai University, Tianjin, 300071, PR China; Institute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing, 100853, PR China; National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, Beijing, 100853, PR China. Electronic address:
The mechanical mismatch of scaffold matrix-mesenchymal stem cells (MSCs) has been a longstanding issue in the clinical application of MSC-based therapy for articular cartilage (AC) regeneration. Existing tissue-engineered scaffolds underestimate the importance of the natural chondrocyte pericellular matrix (PCM). Here, we reveal the temporal and spatial characteristics of collagen distribution around the chondrocytes.
View Article and Find Full Text PDFA novel concept of an acoustic ultrasound wearable for early detection of implant failure.
Sci Rep
December 2024
Center for Surgical Innovation and Engineering, Cedars Sinai Health System, Los Angeles, 90048, USA.
Mechanical failure of medical implants, especially in orthopedic poses a significant burden to the patients and healthcare system. The majority of the implant failures are diagnosed at very late stages and are of mechanical causes. This makes the diagnosis and screening of implant failure very challenging.
View Article and Find Full Text PDFSkill-Learning-Based Trajectory Planning for Robotic Vertebral Plate Cutting: Personalization Through Surgeon Technique Integration and Neural Network Prediction.
Biomimetics (Basel)
November 2024
College of Mechanical and Electronic Engineering, Shandong University of Science and Technology, Qingdao 266590, China.
In robotic-assisted laminectomy decompression, stable and precise vertebral plate cutting remains challenging due to manual dependency and the absence of adaptive skill-learning mechanisms. This paper presents an advanced robotic vertebral plate-cutting system that leverages patient-specific anatomical variations and replicates the surgeon's cutting technique through a trajectory parameter prediction model. A spatial mapping relationship between artificial and patient vertebrae is first established, enabling the robot to mimic surgeon-defined trajectories with high accuracy.
View Article and Find Full Text PDFDual-Engineered Phage Vaccine Platform Facilitates STING Activation for Influenza Protection.
ACS Appl Mater Interfaces
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Department of Cardiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362400, China.
Influenza epidemics remain a global public health challenge. Vaccination with nucleic acid-based vaccines, which trigger strong cellular and humoral immune responses, represents a promising approach for preventing virus infection. However, its effectiveness relies on efficient delivery and an immunoadjuvant.
View Article and Find Full Text PDF[Rational selection of uni-portal full-endoscopic/bi-portal endoscopic spine surgery techniques based on evidence-based medicine].
Zhongguo Gu Shang
December 2024
Senior Department of Orthopaedics, the 4th Medical Center of Chinese PLA General Hospital, Beijing 100048, China.
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