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| http://dx.doi.org/10.1016/j.jcmgh.2015.01.008 | DOI Listing |
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Sounding the alarm in the lung with TL1A.
J Exp Med
June 2024
Division of Gastroenterology and Hepatology, Department of Medicine, Jill Roberts Center and Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA.
Environmental airborne antigens are central to the development of allergic asthma, but the cellular processes that trigger disease remain incompletely understood. In this report, Schmitt et al. (https://doi.
View Article and Find Full Text PDFSerum alarmins and the risk of incident interstitial lung disease in rheumatoid arthritis.
Rheumatology (Oxford)
July 2024
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Objectives: To quantify associations of serum alarmins with risk of rheumatoid arthritis-associated interstitial lung disease (RA-ILD).
Methods: Using serum collected at enrolment, three alarmins (IL-33, thymic stromal lymphopoietin [TSLP] and IL-25) were measured in a multicentre prospective RA cohort. ILD was classified using systematic medical record review.
Sounding the alarmins-The role of alarmin cytokines in asthma.
Allergy
February 2023
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
The alarmin cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, and IL-25 are epithelial cell-derived mediators that contribute to the pathobiology and pathophysiology of asthma. Released from airway epithelial cells exposed to environmental triggers, the alarmins drive airway inflammation through the release of predominantly T2 cytokines from multiple effector cells. The upstream positioning of the alarmins is an attractive pharmacological target to block multiple T2 pathways important in asthma.
View Article and Find Full Text PDFAlarmins and innate lymphoid cells 2 activation: A common pathogenetic link connecting respiratory syncytial virus bronchiolitis and later wheezing/asthma?
Pediatr Allergy Immunol
June 2022
Division of Pediatric Pulmonology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Severe respiratory syncytial virus (RSV) infection in infancy is associated with increased risk of recurrent wheezing in childhood. Both acute and long-term alterations in airway functions are thought to be related to inefficient antiviral immune response. The airway epithelium, the first target of RSV, normally acts as an immunological barrier able to elicit an effective immune reaction but may also be programmed to directly promote a Th2 response, independently from Th2 lymphocyte involvement.
View Article and Find Full Text PDFCaspase 8 sounds the alarm for allergic inflammation.
J Allergy Clin Immunol
April 2022
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Charlestown, Mass; Harvard Medical School, Boston, Mass. Electronic address:
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