Complete Genome Sequences of Three Multidrug-Resistant Clinical Isolates of Serotype 19A with Different Susceptibilities to the Myxobacterial Metabolite Carolacton.

Jannik Donner Boyke Bunk Isabel Schober Cathrin Spröer Simone Bergmann Michael Jarek Jörg Overmann Irene Wagner-Döbler

Genome Announc

Department of Medical Microbiology, Research Group Microbial Communication, Helmholtz Centre for Infection Research, Braunschweig, Germany.

Published: February 2017

The researchers sequenced the genomes of three clinical isolates of serotype 19A that are resistant to drugs and multiple drugs using advanced sequencing technologies.
They utilized both PacBio single-molecule real-time sequencing and Illumina MiSeq sequencing for their analysis.
The genome comparison revealed that these isolates show a high nucleotide sequence similarity to other known strains, specifically Hungary19A-6 and TCH8431/19A.

The full-genome sequences of three drug- and multidrug-resistant clinical isolates of serotype 19A were determined by PacBio single-molecule real-time sequencing, in combination with Illumina MiSeq sequencing. A comparison to the genomes of other pneumococci indicates a high nucleotide sequence identity to strains Hungary19A-6 and TCH8431/19A.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313624	PMC
http://dx.doi.org/10.1128/genomeA.01641-16	DOI Listing

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