For the treatment of skull defect compensation after neurosurgery, a customized artificial bone is often employed owing to its toughness and the relative ease of producing cosmetically good result. However, implants are vulnerable to infection and removal of implant is sometimes necessary. Several other treatment options such as autologous bone graft or free flap are likely to be considered for the secondary reconstruction to avoid reinfection; however, reimplantation of artificial bone is beneficial for the patients, being not concerned with donor site morbidity. The authors consider one of risk factors of infection of artificial bone as dead space between the implant and dura. To attain reduction of the dead space, we have employed thickened artificial bone.Between 2010 and 2014, 6 patients underwent implantation of thickened artificial bone for the secondary reconstruction.First, the infected artificial material was removed with proper debridement. More than 3 months after the closure of the infected wound, tissue expander was inserted beneath the surrounding scalp to ensure the coverage of subsequently implanted artificial bone without skin tension. The thickened artificial bone was designed from the computed tomography findings so as not to leave any dead space between the implant and dura. After optimal expansion of the scalp, the artificial bone was implanted.Postoperative courses were uneventful and the appearance of the cranial vault was satisfactory in all patients.The authors consider the use of the thickened artificial bone is easier and more suitable for patients having a skull defect, particularly in secondary reconstruction.
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http://dx.doi.org/10.1097/SCS.0000000000003507 | DOI Listing |
Mater Today Bio
February 2025
China Uruguay Bio-Nano Pharmaceutical Joint Laboratory, Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, 308 Ningxia Road, Qingdao, 266071, Shandong, China.
Well-designed artificial scaffolds are urgently needed due to the limited self-repair capacity of bone, which hampers effective regeneration in critical defects. Optimal scaffolds must provide physical guidance to recruit cells and immune regulation to improve the regenerative microenvironment. This study presents a novel scaffold composed of dual-sided centripetal microgrooved poly(D,L-lactide-co-caprolactone) (PLCL) film combined with a dynamic hydrogel containing prednisolone (PLS)-loaded Prussian blue nanoparticles (PB@PLS).
View Article and Find Full Text PDFFront Med Technol
January 2025
Ph.D. in Health Science Program, Faculty of Medicine, Mahasarakham University, Mahasarakham, Thailand.
Background: The aging population is increasingly affected by periodontal disease, a condition often overlooked due to its asymptomatic nature. Despite its silent onset, periodontitis is linked to various systemic conditions, contributing to severe complications and a reduced quality of life. With over a billion people globally affected, periodontal diseases present a significant public health challenge.
View Article and Find Full Text PDFPeerJ
January 2025
College of Engineering, University of Tennessee - Knoxville, TN, United States of America.
Objective: The purpose of this study was to investigate the timing and mode of failure of metallic screw-type suture anchors used to attach artificial tendons to bone in an New Zealand White rabbit model.
Study Design: Metal suture anchors with braided composite sutures of varying sizes (United States Pharmacopeia (USP) size 1, 2, or 5) were used to secure artificial tendons replacing both the Achilles and tibialis cranialis tendons in 12 female New Zealand White rabbits. Artificial tendons were implanted either at the time of (immediate replacement, = 8), or four/five weeks after (delayed replacement, = 4) resection of the biological tendon.
J Mech Behav Biomed Mater
January 2025
Laboratory for Biomechanics and Biomaterials (LBB), Department of Orthopedic Surgery, Hannover Medical School, Anna-von-Borries-Strasse 1-7, 30625, Hannover, Germany. Electronic address:
In hip arthroplasty, relative movements between the femoral stem and bone can lead to implant loosening, resulting in extensive bone loss. Acoustic emission (AE) analysis is a promising technique for a nondestructive and noninvasive detection of these relative movements. To develop such a detection method, in vitro investigations using piezoelectric AE sensors on implant stems in artificial or human femora are required to characterize the AE signals induced by loosening.
View Article and Find Full Text PDFSci Data
January 2025
School of Medicine, Anhui University of Science and Technology, Huainan, 232001, China.
Ultrasound is a primary diagnostic tool commonly used to evaluate internal body structures, including organs, blood vessels, the musculoskeletal system, and fetal development. Due to challenges such as operator dependence, noise, limited field of view, difficulty in imaging through bone and air, and variability across different systems, diagnosing abnormalities in ultrasound images is particularly challenging for less experienced clinicians. The development of artificial intelligence (AI) technology could assist in the diagnosis of ultrasound images.
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