PROPELLER technique is widely used in MRI examinations for being motion insensitive, but it prolongs scan time and is restricted mainly to T2 contrast. Parallel imaging can accelerate PROPELLER and enable more flexible contrasts. Here, we propose a multi-step joint-blade (MJB) SENSE reconstruction to reduce the noise amplification in parallel imaging accelerated PROPELLER. MJB SENSE utilizes the fact that PROPELLER blades contain sharable information and blade-combined images can serve as regularization references. It consists of three steps. First, conventional blade-combined images are obtained using the conventional simple single-blade (SSB) SENSE, which reconstructs each blade separately. Second, the blade-combined images are employed as regularization for blade-wise noise reduction. Last, with virtual high-frequency data resampled from the previous step, all blades are jointly reconstructed to form the final images. Simulations were performed to evaluate the proposed MJB SENSE for noise reduction and motion correction. MJB SENSE was also applied to both T2-weighted and T1-weighted in vivo brain data. Compared to SSB SENSE, MJB SENSE greatly reduced the noise amplification at various acceleration factors, leading to increased image SNR in all simulation and in vivo experiments, including T1-weighted imaging with short echo trains. Furthermore, it preserved motion correction capability and was computationally efficient.
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http://dx.doi.org/10.1038/srep42602 | DOI Listing |
N Engl J Med
October 2024
From the Departments of Physiotherapy (T.F., K.G.I.) and Orthopedic Surgery (C.V., A.E.G., P.K.-A., P.H.R., C.H.), Lillebaelt Hospital-University Hospital of Southern Denmark, Vejle Hospital, Vejle, the Departments of Clinical Research (T.F., R.C., S.M.N.) and Regional Health Research (C.V., K.G.I.), University of Southern Denmark, and the Research Unit of Rheumatology, Department of Clinical Research (R.C., S.M.N.), and the Department of Orthopedic Surgery and Traumatology (S.O.), Odense University Hospital, Odense, the Section for Biostatistics and Evidence-based Research, Parker Institute, Bispebjerg and Frederiksberg Hospital (T.F., R.C., S.M.N., K.G.I.), the Department of Orthopedic Surgery and Traumatology, Copenhagen University Hospital Bispebjerg (S.O.), and the Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen (S.O.), Copenhagen, the Department of Orthopedic Surgery, Aarhus University Hospital, and the Department of Clinical Medicine, Aarhus University, Aarhus (I.M., S.S.J.), the University Clinic for Orthopedic Pathways, Elective Surgery Center, Regional Hospital Silkeborg, Silkeborg (L.R.M.), and the Department of Orthopedic Surgery, Næstved Hospital, Næstved (M.J.B., H.Q., M.S.M.) - all in Denmark.
Background: Total hip replacement is routinely recommended for severe hip osteoarthritis, but data from randomized trials are lacking regarding comparison of the effectiveness of this procedure with that of nonsurgical treatment such as resistance training.
Methods: We conducted a multicenter, randomized, controlled trial to compare total hip replacement with resistance training in patients 50 years of age or older who had severe hip osteoarthritis and an indication for surgery. The primary outcome was the change in patient-reported hip pain and function from baseline to 6 months after the initiation of treatment, assessed with the use of the Oxford Hip Score (range, 0 to 48, with higher scores indicating less pain and better function).
Science
October 2024
The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Undernutrition in Bangladeshi children is associated with disruption of postnatal gut microbiota assembly; compared with standard therapy, a microbiota-directed complementary food (MDCF) substantially improved their ponderal and linear growth. Here, we characterize a fatty acid amide hydrolase (FAAH) from a growth-associated intestinal strain of cultured from these children. This enzyme, expressed and purified from hydrolyzes a variety of -acylamides, including oleoylethanolamide (OEA), neurotransmitters, and quorum sensing -acyl homoserine lactones; it also synthesizes a range of -acylamides, notably -acyl amino acids.
View Article and Find Full Text PDFBr J Radiol
October 2024
Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2QX, United Kingdom.
Magnetoencephalography (MEG) is a non-invasive neuroimaging technique that assesses neurophysiology through the detection of the magnetic fields generated by neural currents. In this way, it is sensitive to brain activity, both in individual regions and brain-wide networks. Conventional MEG systems employ an array of sensors that must be cryogenically cooled to low temperature, in a rigid one-size-fits-all helmet.
View Article and Find Full Text PDFRespirology
September 2024
Section of Interventional Pulmonology, Pulmonary Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Background And Objective: Robotic-assisted bronchoscopy (RAB) is an emerging modality to sample pulmonary lesions. Cone-beam computed tomography (CBCT) can be incorporated into RAB. We investigated the magnitude and predictors of patient and staff radiation exposure during mobile CBCT-guided shape-sensing RAB.
View Article and Find Full Text PDFNat Commun
November 2023
Q-CTRL, Sydney, NSW, Australia.
Atom-interferometric quantum sensors could revolutionize navigation, civil engineering, and Earth observation. However, operation in real-world environments is challenging due to external interference, platform noise, and constraints on size, weight, and power. Here we experimentally demonstrate that tailored light pulses designed using robust control techniques mitigate significant error sources in an atom-interferometric accelerometer.
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