Manganese and selenium concentrations in cerebrospinal fluid of seriously ill children.

J Clin Lab Anal

Department of Medical Chemistry and Clinical Biochemistry 2nd Faculty of Medicine, Faculty Hospital Motol, Charles University, Prague, Czech Republic.

Published: November 2017

Background: The homeostasis of essential trace elements such as selenium and manganese may be altered in patients with severe diseases of various etiologies (trauma brain injuries, tumors, leukemias, lymphomas, neurological diseases).

Methods: Concentration of manganese and selenium were determined in cerebrospinal fluid by electrothermal atomic absorption spectrometry in 50 hospitalized children with various clinical ethiologies including oncological, neurological, and brain related diseases.

Results: The concentrations of manganese in cerebrospinal fluid of children were 0.97±0.67 μg/L. The concentrations of selenium were 13.3±3.5 μg/L. The concentrations were similar as published in adults. The values did not correlated with the age, gender and severity of the disease.

Conclusion: We evaluated values of selenium and manganese in cerebrospinal fluid of seriously diseased children.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817268PMC
http://dx.doi.org/10.1002/jcla.22122DOI Listing

Publication Analysis

Top Keywords

cerebrospinal fluid
16
manganese selenium
8
fluid seriously
8
selenium manganese
8
manganese cerebrospinal
8
manganese
5
concentrations
4
selenium concentrations
4
cerebrospinal
4
concentrations cerebrospinal
4

Similar Publications

Aim: Successful deep brain stimulation (DBS) requires precise electrode placement. However, brain shift from loss of cerebrospinal fluid or pneumocephalus still affects aim accuracy. Multidetector computed tomography (MDCT) provides absolute spatial sensitivity, and intraoperative cone-beam computed tomography (iCBCT) has become increasingly used in DBS procedures.

View Article and Find Full Text PDF

Aim: To assess the changes of intracranial pressure waveforms (ICPW) acquired noninvasively in a set of acute hydrocephalus patients prior to and posterior to interventions.

Material And Methods: Patients with clinical and radiological diagnoses of hydrocephalus were evaluated for alterations in ICPW by means of a system that detects cranial micro expansions just before and immediately after interventions. The system quantified the difference between ICPW peaks (P1 and P2), providing the P2/P1 ratio.

View Article and Find Full Text PDF

The growing prevalence of the Alzheimer's disease (AD) is an increasing public health concern that led to French recommendations for timely AD diagnosis and patient management as well as a territorial coverage of specialized structures [Memory Centers including Resources and Memory Research Centers (RMRC) and Memory Consultations (MC)]. In view of the potential availability of Disease Modifying Therapies (DMTs), this French observatory aimed to describe the current organization of the Memory Centers, and the care pathway of patients suffering from early AD. Overall, 12 of the 28 RMRC and 44 of the 250 MC solicited by the Federation of Memory Centers participated in this study.

View Article and Find Full Text PDF

Masticatory muscle changes on magnetic resonance imaging of dogs with compared to meningoencephalitis of unknown origin.

Front Vet Sci

January 2025

Anderson Moores Veterinary Specialists, Linnaeus Veterinary Limited, Winchester, United Kingdom.

Infectious meningoencephalitides represent an important differential diagnosis for meningoencephalitis of unknown origin (MUO) in dogs. Treatment of the latter requires immunosuppression, but laboratory test results for infectious agents may take several days to return. This study investigated whether the presence of masticatory muscle changes on magnetic resonance imaging (MRI) of the head can be used to distinguish dogs with neosporosis from those with MUO at the time of diagnosis.

View Article and Find Full Text PDF

Background: Emerging evidence underscores the comorbidity mechanisms among autoimmune diseases (AIDs), with innovative technologies such as single-cell RNA sequencing (scRNA-seq) significantly advancing the explorations in this field. This study aimed to investigate the shared genes among three AIDs-Multiple Sclerosis (MS), Systemic Lupus Erythematosus (SLE), and Rheumatoid Arthritis (RA) using bioinformatics databases, and to identify potential biomarkers for early diagnosis.

Methods: We retrieved transcriptomic data of MS, SLE, and RA patients from public databases.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!