Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292927 | PMC |
| http://dx.doi.org/10.1212/NXI.0000000000000329 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival.
EMBO Rep
January 2025
Cellular and Molecular Physiology, Institute of Systems Molecular and Integrative Biology, University of Liverpool, Crown St, Liverpool, L69 3BX, UK.
Cancer cells often display centrosome amplification, requiring the kinesin KIFC1/HSET for centrosome clustering to prevent multipolar spindles and cell death. In parallel siRNA screens of deubiquitinase enzymes, we identify OTUD6B as a positive regulator of KIFC1 expression that is required for centrosome clustering in triple-negative breast cancer (TNBC) cells. OTUD6B can localise to centrosomes and the mitotic spindle and interacts with KIFC1.
View Article and Find Full Text PDFFeatures and results availability of non-commercial Spanish COVID-19 trials: a systematic review of clinical trial registers and corresponding literature.
Eur J Clin Pharmacol
January 2025
Biostatistics and Epidemiology Unit, Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid, Madrid, Spain.
Objectives: This study aimed to characterize non-commercial Spanish COVID-19 trials and to determine the availability of results. Differences in outcomes according to the interventions assessed (medicines, non-medicines) will also be determined.
Methods: This systematic review was conducted in March 2024 by searching non-commercial Spanish COVID-19 trials on four registers (EUCTR, Clinical.
DARPin-induced reactivation of p53 in HPV-positive cells.
Nat Struct Mol Biol
January 2025
Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt, Germany.
Infection of cells with high-risk strains of the human papillomavirus (HPV) causes cancer in various types of epithelial tissue. HPV infections are responsible for ~4.5% of all cancers worldwide.
View Article and Find Full Text PDFAn Electroglottographic and Acoustic Study on Mandarin Speech in Male Heroin Users.
J Voice
January 2025
Department of Audio, Video, and Electronic Forensics, Academy of Forensic Science, Shanghai, China; Shanghai Forensic Service Platform, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai, China.
Drug abuse can cause severe damage to the human speech organs. The vocal folds are one of the important speech organs that produce voice through vibration when airflow passes through. Previous studies have reported the negative effects of drugs on speech organs, including the vocal folds, but there is still limited research on relevant field.
View Article and Find Full Text PDFInvited review: Social housing of dairy calves: management factors affecting calf behavior, performance, and health - A systematic review.
J Dairy Sci
January 2025
Department of Animal and Veterinary Sciences, Aarhus University, Tjele, Denmark.
Given increasing adoption of social housing for pre-weaned dairy calves, we conducted a systematic review to summarize existing literature describing effects of social housing management factors on behavior, performance, and health of dairy calves. Included articles addressed interventions applied to pre-weaned, socially housed dairy calves, encompassing age at introduction to social housing, group composition (size, stocking density, within-group age range, stability), and housing environment (space allowance, enrichment provision). Outcome measures addressed behavior, including social behavior, locomotor behavior, feeding behavior, abnormal oral behavior, and behavioral responses during tests; performance, including body measurements and weight gain; and health, including clinical health scores and mortality rate.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!