A Novel Computer-Aided Approach for Parametric Investigation of Custom Design of Fracture Fixation Plates.

Comput Math Methods Med

College of Internet of Things Engineering, Hohai University, Changzhou, China; Changzhou City Key Lab of Orthopedic Implants Digital Technology, Changzhou, China.

Published: April 2017

The present study proposes an integrated computer-aided approach combining femur surface modeling, fracture evidence recover plate creation, and plate modification in order to conduct a parametric investigation of the design of custom plate for a specific patient. The study allows for improving the design efficiency of specific plates on the patients' femur parameters and the fracture information. Furthermore, the present approach will lead to exploration of plate modification and optimization. The three-dimensional (3D) surface model of a detailed femur and the corresponding fixation plate were represented with high-level feature parameters, and the shape of the specific plate was recursively modified in order to obtain the optimal plate for a specific patient. The proposed approach was tested and verified on a case study, and it could be helpful for orthopedic surgeons to design and modify the plate in order to fit the specific femur anatomy and the fracture information.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288515PMC
http://dx.doi.org/10.1155/2017/7372496DOI Listing

Publication Analysis

Top Keywords

computer-aided approach
8
parametric investigation
8
plate
8
plate modification
8
plate specific
8
specific patient
8
specific
5
novel computer-aided
4
approach
4
approach parametric
4

Similar Publications

Development and Application of a Comprehensive Non-targeted Screening Strategy for Fentanyl Analogues.

J Hazard Mater

January 2025

Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610213, China; Key Laboratory of Monitoring and Assessment on Novel Food Raw Materials, State Administration for Market Regulation, Chengdu 611130, China. Electronic address:

The growing abuse of fentanyl and its analogues (FTNs) presents a substantial public health threat, prompting the introduction of regulatory controls by government authorities. Nevertheless, existing screening strategies for FTNs are primarily based on targeted or non-targeted approaches that utilize a limited set of mass spectrometry fragmentation data, which are far from meeting the needs of class scheduling. In this study, a comprehensive non-targeted screening strategy for FTNs was developed.

View Article and Find Full Text PDF

The farnesoid X receptor (FXR) regulates key physiological processes, such as bile acid homeostasis and lipid metabolism, making it an important target for drug discovery. However, the overactivation of FXR often leads to adverse effects. This study presents the development of a novel fluorescent probe utilizing the computer-aided drug design (CADD) approach to optimize linkers between more potent warhead and FITC fluorescent groups.

View Article and Find Full Text PDF

Benefit from public unlabeled data: A Frangi filter-based pretraining network for 3D cerebrovascular segmentation.

Med Image Anal

January 2025

School of Engineering Medicine and School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China; Key Laboratory of Big DataBased Precision Medicine (Beihang University), Ministry of Industry and Information Technology of China, Beijing, 100191, China; CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China; National Key Laboratory of Kidney Diseases, Beijing, 100853, China. Electronic address:

Precise cerebrovascular segmentation in Time-of-Flight Magnetic Resonance Angiography (TOF-MRA) data is crucial for computer-aided clinical diagnosis. The sparse distribution of cerebrovascular structures within TOF-MRA images often results in high costs for manual data labeling. Leveraging unlabeled TOF-MRA data can significantly enhance model performance.

View Article and Find Full Text PDF

Mandibular Reconstruction With a Patient-Specific Implant Following Surgical Excision of an Acanthomatous Ameloblastoma in a Dog.

J Vet Dent

January 2025

Department of Dentistry, Oral and Maxillo-facial Surgery, Eastcott Veterinary Referrals, Part of Linnaeus Group, Swindon, UK.

Canine acanthomatous ameloblastoma (CAA) is an invasive benign epithelial odontogenic tumour most commonly affecting the mandible of large breed dogs. To the author's knowledge, this report describes the first computer-aided design patient-specific implant (PSI) that has been placed for a critical sized bone defect in mandibular reconstruction of a dog in the UK. The aim was to restore mandibular stability using a regenerative approach combining a titanium locking plate and compression-resistant matrix infused with recombinant human bone morphogenetic protein-2 (rhBMP-2) to bridge the 85 mm mandibular defect created by a segmental mandibulectomy.

View Article and Find Full Text PDF

Diabetic retinopathy (DR) presents a significant concern among diabetic patients, often leading to vision impairment or blindness if left untreated. Traditional diagnosis methods are prone to human error, necessitating accurate alternatives. While various computer-aided systems have been developed to assist in DR detection, there remains a need for accurate and efficient methods to classify its stages.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!