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How Irregular Geometry and Flow Waveform Affect Pulsating Arterial Mass Transfer.
J Biomech Eng
December 2024
Department of Mechanical Engineering, Liberty University, Lynchburg, VA 24550.
Alzheimer's disease is a progressive degenerative condition that has various levels of effect on one's memory. It is thought to be caused by a buildup of protein in small fluid-filled spaces in the brain called perivascular spaces (PVS). The PVS often takes on the form of an annular region around arteries and is used as a protein-clearing system for the brain.
View Article and Find Full Text PDFFlow in temporally and spatially varying porous media: a model for transport of interstitial fluid in the brain.
J Math Biol
April 2024
Department of Mechanical Engineering, Watson College of Engineering and Applied Science, State University of New York at Binghamton, Binghamton, NY, 13902, USA.
Flow in a porous medium can be driven by the deformations of the boundaries of the porous domain. Such boundary deformations locally change the volume fraction accessible by the fluid, creating non-uniform porosity and permeability throughout the medium. In this work, we construct a deformation-driven porous medium transport model with spatially and temporally varying porosity and permeability that are dependent on the boundary deformations imposed on the medium.
View Article and Find Full Text PDFEosinophilic Annular Erythema Responding to Doxycycline.
Cureus
October 2023
Department of Dermatology, Oregon Health and Science University School of Medicine, Portland, USA.
Eosinophilic annular erythema (EAE) is a rare skin disease characterized by relapsing and remitting pruritic, annular erythematous plaques and tissue eosinophilia. A 39-year-old male presented with a mildly pruritic, relapsing, and remitting urticarial rash. A biopsy revealed superficial and deep perivascular dermatitis with numerous eosinophils and some neutrophils, with an absence of flame figures.
View Article and Find Full Text PDFThe directional flow generated by peristalsis in perivascular networks-Theoretical and numerical reduced-order descriptions.
J Appl Phys
November 2023
Department of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, San Diego, California 92093-0411, USA.
Directional fluid flow in perivascular spaces surrounding cerebral arteries is hypothesized to play a key role in brain solute transport and clearance. While various drivers for a pulsatile flow, such as cardiac or respiratory pulsations, are well quantified, the question remains as to which mechanisms could induce a directional flow within physiological regimes. To address this question, we develop theoretical and numerical reduced-order models to quantify the directional (net) flow induceable by peristaltic pumping in periarterial networks.
View Article and Find Full Text PDFEffect of intravenous levosimendan or milrinone on left atrial pressure in patients undergoing off-pump coronary artery bypass grafting-A prospective double-blind, randomized controlled trial.
Ann Card Anaesth
November 2023
Department of Cardio Thoracic Vascular Anaesthesiology, Institute of Post Graduate Medical Education and Research (IPGME&R), Kolkata, West Bengal, India.
Background: Maintaining a low left atrial pressure (LAP) in off-pump coronary artery bypass grafting (OPCAB) is desirable. This study was done to compare the effects of intravenous levosimendan or milrinone on LAP at different stages of OPCAB.
Materials And Methods: After institutional ethics committee clearance, this two-arm double-blind randomized control trial was done in 44 adult patients with triple vessel coronary artery disease undergoing OPCAB at cardiac OT of IPGME&R, Kolkata.
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