Acute hemorrhage was accompanied by impairments in electron transport and energy functions of rabbit liver mitochondria as well as by a decrease in activity of multienzyme systems responsible for electron transfer via redox chain. The impairments observed correlated distinctly with the rate of hypoxia and of metabolic acidosis. In the hemorrhage NADH oxidation occurred mainly via rotenon-insensitive NADH oxidase while the cytochrome oxidase activity was maintained at a relatively high level.
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