AI Article Synopsis
Article Abstract
Purpose: The aim of this study was to compare signs of dry eye between ulcerative colitis (UC) patients and healthy subjects.
Methods: Fifteen patients with UC (group 1) and 15 healthy subjects (group 2) were enrolled in this study. Tear volume measurement, Schirmer-I test with no anesthetic, tear break-up time, and conjunctival impression cytology (CIC) were evaluated in both groups.
Results: Patients with UC showed lower tear volumes when compared with healthy subjects (P<0.05). There was a statistically significant difference in distribution of CIC grades between groups 1 and 2 (P<0.05). Tear break-up time and Schirmer-I measurements were significantly lower in group 1 compared with group 2 (P<0.05).
Conclusions: The results of this study indicate that UC is associated with demonstrable disturbances in tear function and conjunctival cytology.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/ICL.0000000000000380 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Role of Scanning Electron Microscopy in the Evaluation of Conjunctival Microvilli as an Early Biomarker of Ocular Surface Health: A Literature Review.
J Clin Med
December 2024
Eye Clinic, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, 80131 Naples, Italy.
Microvilli are bristle-like protuberances of the plasma membrane, which express the vitality of mucous and epithelial cells; their alteration indicates a condition of cellular suffering in a predictive sense, making it possible to establish how much an inflammatory state or toxic conditions affect cellular functionality. In this article, the authors evaluate the applications of scanning electron microscopy (SEM) examination to impression cytology (IC) of the bulbar conjunctiva for the assessment of microvillar alteration as an early ultrastructural indicator of ocular surface health. This method offers several advantages, starting with its simplicity: it involves the non-invasive application of a strip of bibulous paper to the bulbar or tarsal conjunctiva.
View Article and Find Full Text PDFIncreased inflammatory mediators in the ocular surface tissue in keratoconus.
Mol Vis
November 2024
Department of Ophthalmology and Visual Science, Federal University of São Paulo, São Paulo, Brazil, UNIFESP.
Article Synopsis
- * Researchers collected and analyzed tear samples from 30 KC patients and 23 controls, measuring levels of various cytokines and gene expression using techniques like flow cytometry and PCR.
- * While higher levels of IL-5 and IL-6 were found in KC patients' conjunctival epithelium, there were no significant differences in cytokine concentrations in tear films between the two groups, though some gene expressions were elevated in the KC group.
Evaluation of ocular surface inflammation and systemic conditions in patients with systemic lupus erythematosus: a cross-sectional study.
BMC Ophthalmol
November 2024
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmic and Visual Science Key Laboratory, Beijing, China.
Objective: The cross-sectional study was designed to evaluate the association of ocular surface inflammation with systemic conditions in patients with systemic lupus erythematosus (SLE).
Methods: The study enrolled 30 SLE patients and 30 controls. Ocular symptoms were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire.
Bilateral limbal stem cell deficiency (LSCD) is a significant cause of corneal blindness and is more difficult to treat, as compared with unilateral LSCD because no source of autologous limbal stem cells (LSCs) remains in these patients. Thus, bilateral patients could be candidates for treatment with allogeneic LSC transplants that require long-term systemic immunosuppression therapy. Thus, if possible, for the correct candidates, using autologous LSCs could be a preferred treatment.
View Article and Find Full Text PDFEffects of Glaucoma Treatment on Ocular Surface and Tear Functions: Comparison of Trabeculectomy and Antiglaucoma Drops.
Turk J Ophthalmol
October 2024
Mersin University Faculty of Medicine, Department of Ophthalmology, Mersin, Türkiye.
Article Synopsis
- The study aimed to compare tear function and ocular surface disease (OSD) in glaucoma patients treated with medications in one eye and trabeculectomy surgery in the other.
- The researchers analyzed data from 19 patients who had surgery at least six months prior, assessing various eye health indicators compared to a control group of healthy individuals.
- Results indicated that both treatment methods similarly affected OSD, with some improvement noted over time, but neither approach showed a significant advantage over the other regarding the incidence of OSD.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!