Rapid detection and precise evaluation of myocardial viability is necessary to aid in clinical decision making whether to recommend revascularization for patients with myocardial infarction (MI). Three novel F-labeled 1-hydroxyanthraquinone derivatives were synthesized, characterized, and evaluated as potential necrosis avid imaging agents for assessment of myocardial viability. Among these tracers, [F]FA3OP emerged as the most promising compound with best stability and highest targetability. Clear PET images of [F]FA3OP were obtained in rat model of myocardial infarction and reperfusion at 1 h after injection. In addition, the possible mechanisms of [F]FA3OP for necrotic myocardium were discussed. The results showed [F]FA3OP may bind DNA to achieve targetability to necrotic myocardium by intercalation. In summary, [F]FA3OP was a more promising "hot spot imaging" tracer for rapid visualization of necrotic myocardium.
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| http://dx.doi.org/10.1021/acsmedchemlett.6b00398 | DOI Listing |
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