This multicenter prospective case series study aimed to evaluate the outcome of periodontal regenerative therapy using a deproteinized bovine bone mineral (DBBM) in combination with a collagen barrier (CB) in the treatment of intrabony defects. A total of 36 nonsmoking patients with chronic periodontitis were recruited in five centers in Japan. All patients had at least one intrabony defect of ≥ 3 mm. The surgical procedures included access for debridement using a papilla preservation technique. Defects were filled with DBBM and covered with CB. Clinical evidence after 6 months supported the effectiveness of the combination therapy in the treatment of intrabony defects.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.11607/prd.2888 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The clinical effect of bone perforations in periodontal regeneration and alveolar socket preservation: a systematic review with meta-analysis.
Clin Oral Investig
January 2025
Division of Prosthodontics and Implant Prosthodontics, Department of Surgical Sciences, University of Genova, Genova, Italy.
Objectives: The present systematic review aimed to evaluate if cortical bone perforation is effective in enhancing periodontal surgery and guided bone regeneration (GBR) in humans.
Materials And Methods: Electronic search was performed in PubMed, Scopus and Cochrane CENTRAL up to October 31st, 2023. Grey literature was also searched.
Background: The adjunctive use of connective tissue grafts (CTGs) in the periodontal regeneration of intrabony defects has been proposed to prevent or limit postoperative gingival recession. However, there is limited evidence regarding the long-term clinical performance of this approach.
Methods: This article presents the five-year follow-up outcomes of a combination therapy using CTG, bone substitutes, and biologics for the treatment of deep intrabony defects associated with gingival recession.
Saving a hopeless tooth with a four-wall bone defect: A case report.
Clin Adv Periodontics
December 2024
Department of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Background: Recombinant human fibroblast growth factor-2 (rhFGF-2) has been shown to effectively promote the formation of new periodontal tissues, and its efficacy has been demonstrated in clinical settings. Moreover, the clinical and radiographic outcomes in the treatment of periodontal infrabony defects can be improved by using rhFGF-2 in combination with a bone substitute. Here, we present a case of four-wall bone defect in a tooth treated by combination regenerative therapy using rhFGF-2 and beta-tricalcium phosphate (β-TCP).
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the effectiveness of combining enamel matrix derivatives (EMD) with bone substitutes (BG) in treating periodontal defects compared to using bone substitutes alone.
- Researchers analyzed data from 9 randomized controlled trials with a minimum follow-up of 6 months, focusing on intrabony and furcation defects.
- The results showed that the EMD+BG combination led to a significant improvement in clinical attachment levels for intrabony defects over a 12-month period, but no benefits were observed for furcation defects.
CALCIUM PHOSPHATE GRAFTS COMBINED WITH GUIDED TISSUE REGENERATION IN THE TREATMENT OF PERIODONTAL BONY DEFECTS- A SYSTEMATIC REVIEW AND META-ANALYSIS.
J Evid Based Dent Pract
December 2024
Assistant Professor, Department of Restorative Dentistry, Maurice H. Kornberg School of Dentistry, Temple University, Philadelphia, PA.
Background: The objective of this systematic review is to assess the clinical outcomes of intrabony and furcation defects treated using a regenerative approach with calcium phosphate (CP) grafts combined plus guided tissue regeneration (GTR) membrane in comparison to open flap debridement (OFD).
Method: A review protocol was created under PRISMA checklist to find randomized clinical trials (RCTs) in English that compared CPs plus GTR with OFD in humans with intrabony and/or furcation defects. Both electronic and manual searches were conducted.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!