AI Article Synopsis
- * In this study, various non-histopathologic tests (COBAS®, Cervista®, and saliva analysis) were evaluated against the standard p16 staining method for diagnosing HPV-related tumors.
- * Results show that COBAS® FNA and saliva tests accurately identify HPV status, potentially reducing the need for invasive diagnostic procedures and aiding in the diagnosis of cases with unknown origins.
Article Abstract
Background: Human papilloma virus (HPV) has been implicated in the development of a large proportion of oropharyngeal squamous cell carcinoma (OPSCC). Current techniques used to diagnose HPV etiology require histopathologic analysis. We aim to investigate the diagnostic accuracy of a new application non-histopathologic diagnostic tests to help assist diagnosis of HPV-related oropharyngeal tumors.
Methods: Patients with OPSCC with nodal metastasis were consecutively recruited from a multidisciplinary cancer clinic. Appropriate samples were collected and analyzed. The various tests examined included COBAS® 4800, Cervista® HR and Genotyping. These tests were compared to p16 staining, which was used as the diagnostic standard. StataIC 14.2 was used to perform analysis, including sensitivity, specificity and receiver operator characteristic [ROC] curves.
Results: The COBAS® FNA (area under ROC 0.863) and saliva (area under ROC 0.847) samples performed well in diagnosing HPV positive and negative tumors. Samples tested with Cervista® did not corroborate p16 status reliably. We were able to increase the diagnostic yield of the COBAS® FNA samples by applying the results of the saliva test to negative FNA samples which correctly identified 11 additional p16 positive tumors (area under ROC 0.915).
Conclusion: Surrogate testing for HPV using alternate methods is feasible and closely predicts the results of standard diagnostic methods. In the future, these could minimize invasive procedures for diagnosing HPV-related oropharyngeal cancer, but also help to diagnose and treat patients with unknown primaries.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307773 | PMC |
| http://dx.doi.org/10.1186/s40463-017-0189-z | DOI Listing |
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