AI Article Synopsis
- The intestinal microbiota has been recognized as a significant factor in the development of obesity and related metabolic disorders over the past decade.
- Studies in animal models suggest a causal relationship between gut bacteria and obesity, but similar evidence in humans is limited to associations rather than definitive cause-and-effect.
- This review aims to critically evaluate how the composition of intestinal microbes may influence the onset, prevention, and management of obesity and conditions like type 2 diabetes.
Article Abstract
The potential role of intestinal microbiota in the etiology of various human diseases has attracted massive attention in the last decade. As such, the intestinal microbiota has been advanced as an important contributor in the development of obesity and obesity-related metabolic dysfunctions, amongst others. Experiments in animal models have produced evidence for a causal role of intestinal microbiota in the etiology of obesity and insulin resistance. However, with a few exceptions, such causal relation is lacking for humans and most publications merely report associations between intestinal microbial composition and metabolic disorders such as obesity and type 2 diabetes. Thus, the reciprocal relationship between the bacteria and these metabolic disorders remains a matter of debate. The main objective of this review is to critically assess the driving role of intestinal microbe composition in the etiology, prevention, and treatment of obesity and obesity-related metabolic dysfunction, including type 2 diabetes.
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| http://dx.doi.org/10.1053/j.gastro.2016.12.048 | DOI Listing |
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