AI Article Synopsis
- A 17-year-old female wolf had a tumor in her right lung that was stuck to the chest cavity.
- Histopathological analysis showed that the tumor was made up of small cuboidal cells and had areas of tissue damage and blood clots.
- The tumor was diagnosed as a pulmonary neuroendocrine tumor due to its similarity to carcinoids and specific protein expressions found in the cells.
Article Abstract
A 17-year-old female wolf (Canis lupus lupus) had a right lung mass that was adhered to the thoracic cavity. Histopathological examination revealed that the mass consisted of sheets, cord or ribbon-like structures of monotonous, small, cuboidal cells with round, oval or short-spindle nuclei and scant clear cytoplasm, demarcated by a fine fibrovascular stroma. Focal necrosis, congestion and thrombi were observed. Immunohistochemically, the tumor cells diffusely expressed cytokeratin AE1/AE3, and some expressed chromogranin A, neural cell adhesion molecule (CD56) and thyroid transcription factor-1. The number of proliferating cell nuclear antigen-positive tumor cells was low. A diagnosis of pulmonary neuroendocrine tumor was based on the resemblance to carcinoids.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383182 | PMC |
| http://dx.doi.org/10.1292/jvms.16-0490 | DOI Listing |
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