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Health care systems and policies for older adults in Nepal: new challenges for a low-middle income country.
Discov Public Health
December 2024
Present Address: Department of Global Health, Georgetown University School of Health, Washington, DC USA.
Background: Nepal, like other low- and middle-income countries, is experiencing a rapid increase in the number of older adults and the rate of aging in the population. This has increased the number of older adults with age-associated chronic illnesses, which in turn will escalate the demand for specialized healthcare and long-term care in Nepal. However, very little is known regarding the current healthcare system and health policies for older adults in Nepal.
View Article and Find Full Text PDFIdentification of the oncogenic role and clinical implication of in Colon Adenocarcinoma.
J Cancer
January 2025
Department of Oncology, Geriatric Medical Center, Wuxi Second Geriatric Hospital, Wuxi Huishan Second People's Hospital, Wuxi, 214174, Jiangsu, China.
Colorectal carcinoma (CRC) is a highly prevalent and life-threatening disease with multi-stage progression, characterized by diverse molecular expression patterns at distinct stages, making treatment particularly challenging. Early detection and diagnosis of CRC are vital and can greatly benefit from the discovery of effective biomarkers. Researchers have identified novel gene signatures that play pivotal roles in specific CRC types or stages.
View Article and Find Full Text PDFSepsis in Aging Populations: A Review of Risk Factors, Diagnosis, and Management.
Cureus
December 2024
Internal Medicine, Al-Baha University, Al-Baha, SAU.
Sepsis remains a significant global health concern, particularly among aging populations. This comprehensive review examines the complex interplay between aging and sepsis, focusing on risk factors, diagnostic challenges, and management strategies specific to older adults. The study explores the physiological changes associated with aging that contribute to increased sepsis susceptibility, including immunosenescence and chronic inflammation.
View Article and Find Full Text PDFReceptor-Interacting Protein Kinase 3-Mediated Modulation of Endothelial Cell Necroptosis and Mitochondrial Dysfunction through AMPK/Drp1 Signaling Pathway: Insights into the Pathophysiological Mechanisms of Lipopolysaccharide-Induced Acute Lung Injury.
Int J Med Sci
January 2025
Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Receptor-interacting protein 3 (Ripk3) plays a crucial part in acute lung injury (ALI) by regulating inflammation-induced endothelial damage in the lung tissue. The precise mechanisms through which Ripk3 contributes to the endothelial injury in ALI still remain uncertain. In the current research, we employed Ripk3-deficient (Ripk3) mice to examine the role of Ripk3 in ALI progression, focusing on its effects on endothelial cells (ECs), mitochondrial damage and necroptosis.
View Article and Find Full Text PDFPreserved social facilitation and preferential processing of partner-relevant information in Huntington's disease.
Brain Commun
December 2024
Center Neuropsychiatry, Department of Neurosciences, Psychiatry Research Group, Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium.
This scientific commentary refers to 'The joint memory effect: challenging the selfish stigma in Huntington's disease?', by Dalléry . (https://doi.org/10.
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