AI Article Synopsis
- * These tumors likely arise from the misplacement of totipotent stem cells during early development, primarily growing along the pineal-suprasellar axis in the brain, leading to varied symptoms based on their location.
- * The study reviews two specific cases of pineal GCTs and discusses the significance of histopathologies and biomarkers in their management and outcomes.
Article Abstract
Pineal germ cell tumors (GCTs) are primarily seen in pediatric and Asian populations. These tumors are divided into germinomatous and non-germinomatous GCTs (NGGCTs). GCTs are thought to arise by misplacement of totipotent stem cells en route to gonads during embryogenesis. Intracranial GCTs display an affinity to develop along the pineal-suprasellar axis and have variable manifestations dependent upon the location of the tumor. Management and outcomes are driven by histopathologies. In this study, we highlight two cases of pineal GCTs and present a review of the literature with an emphasis on histopathologies and biomarkers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908809 | PMC |
| http://dx.doi.org/10.1016/j.jocn.2016.12.024 | DOI Listing |
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