Objectives: To evaluate the radiation dose and image quality of cerebral CT angiography (CTA) at 70kVp with 30mL iodinated contrast agent.

Methods: One hundred patients were prospectively classified into two groups: Group A (n=50), 120kVp cerebral CTA with 60mL iodinated contrast agent reconstructed by filtered back projection (FBP) and Group B (n=50), 70kVp with 30mL iodinated contrast agent reconstructed by sinogram-affirmed iterative reconstruction (SAFIRE). CT values, noise, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the internal carotid artery (ICA) and middle cerebral artery (MCA) were measured. Subjective image quality was evaluated. Effective dose (ED) was calculated.

Results: The mean CT values of the ICA and MCA of Group B were higher than those of Group A (all P<0.001). The mean noise of Group A was lower than that of Group B (P<0.001). SNR, SNR and CNR, CNR of Group A were higher than Group B (all P<0.001). There was no difference in vessel sharpness, noise, and overall quality between the two groups (all P>0.05). ED of Group B (0.2±0.0mSv) was lower than Group A (1.3±0.1 mSv) (p<0.001).

Conclusion: Cerebral CTA with iterative reconstruction at 70kVp and 30mL iodinated contrast agent is feasible, allowing for substantial dose reduction compared with conventional cerebral CTA protocol.

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http://dx.doi.org/10.1016/j.ejrad.2016.12.037DOI Listing

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