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Background: Group A Streptococci (GAS) may cause infections of the pharynx and soft tissues and invasive infections in children (iGAS). A significant increase in severe iGAS infections has been reported in Europe since the fall of 2022.

Objectives: This retrospective study aims to analyse clinical data of children with invasive and non-invasive GAS infections in the post-COVID-19 pandemic era, searching for predisposing factors to developing invasive infections.

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: Multi-organ failure (MOF) often complicates advanced heart failure (HF), contributing to a poor prognosis. The Model of End-Stage Liver Disease 3.0 (MELD-3.

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Case identification and healthcare utilization in the years prior to a first mania diagnosis.

J Affect Disord

November 2024

Mongan Institute, Massachusetts General Hospital, Boston, MA, United States of America; Department of Medicine, Harvard Medical School, Boston, MA, United States of America; Department of Health Care Policy, Harvard Medical School, Boston, MA, United States of America.

Article Synopsis
  • The study looked at how to find people who were newly diagnosed with bipolar disorder and had episodes of mania by using a big database in Massachusetts.
  • Researchers found 583 young individuals who seemed to have new bipolar disorder diagnoses in 2016, and many had seen doctors for other issues before their diagnosis.
  • The research showed that it's important to look at a lot of medical history from different sources to correctly identify new cases of bipolar disorder with mania.
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Background: Poor sleep is prevalent in adolescents with bipolar disorder, precedes illness onset, and is associated with worse mood symptoms. We examined interrelationships between sleep quality and mood symptoms in adolescents with bipolar disorder, particularly effects of sleep quality on emergent mood symptoms.

Methods: Adolescents with bipolar disorder participated in a two-year longitudinal treatment study.

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