An artificial ionic mechanotransducer skin with an unprecedented sensitivity over a wide spectrum of pressure by fabricating visco-poroelastic nanochannels and microstructured features, directly mimicking the physiological tactile sensing mechanism of Piezo2 protein is demonstrated. This capability enables voice identification, health monitoring, daily pressure measurements, and even measurements of a heavy weight beyond capabilities of human skin.
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Piezo channels in JG cells do not regulate renin expression or renin release to the circulation.
Clin Sci (Lond)
December 2024
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, U.S.A.
Article Synopsis
- Renin-expressing juxtaglomerular (JG) cells have a mechanism that senses pressure and regulates renin release based on changes in blood flow.
- The study investigates whether Piezo2 receptors, known for their role in detecting touch, play a role in controlling renin synthesis and release in JG cells.
- Results show that Piezo2 channels are not necessary for renin release or synthesis in JG cells under normal or stressed conditions, suggesting that other mechanisms need to be identified.
Piezo1 in skin wound healing and related diseases: Mechanotransduction and therapeutic implications.
Int Immunopharmacol
October 2023
College of Pharmacy, Zunyi Medical University, Zunyi 563006, China; Key Lab of the Basic Pharmacology of the Ministry of Education & Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563006, China; School Medical Office, Zunyi Medical University, Zunyi 563006, China; Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland (UQ), Brisbane, QLD 4072, Australia; School of Biomedical Sciences, Translational Research Institute (TRI), Queensland University of Technology (QUT), Brisbane, QLD 4102, Australia. Electronic address:
Article Synopsis
- Skin wound healing is a complex process that includes inflammation, tissue growth, and scar formation, all influenced by physical forces.
- A protein called Piezo1 is really important in helping the skin respond to these physical signals, acting like a sensor.
- This article talks about how Piezo1 helps with skin healing and could be useful for treating skin injuries and diseases.
Mechanotransduction events at the physiological site of touch detection.
Elife
January 2023
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, United States.
Afferents of peripheral mechanoreceptors innervate the skin of vertebrates, where they detect physical touch via mechanically gated ion channels (mechanotransducers). While the afferent terminal is generally understood to be the primary site of mechanotransduction, the functional properties of mechanically activated (MA) ionic current generated by mechanotransducers at this location remain obscure. Until now, direct evidence of MA current and mechanically induced action potentials in the mechanoreceptor terminal has not been obtained.
View Article and Find Full Text PDFKeratinocyte PIEZO1 modulates cutaneous mechanosensation.
Elife
September 2022
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Wauwatosa, United States.
Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a key keratinocyte mechanotransducer.
View Article and Find Full Text PDFBlood vessels sense dermal stiffness via a novel mechanotransducer, APJ.
Angiogenesis
May 2022
Shiseido Global Innovation Center, 1-2-11, Takashima, Nishi-ku, Yokohama, 220-0011, Japan.
Microvascular dysfunction accompanied by a dramatic alteration of stable capillary structure is a major hallmark of numerous age-related diseases. In skin, although the role of angiogenesis during dermal reconstitution is well documented, the functional relevance of the extracellular matrix (ECM) stiffness to vascular remodeling and its molecular mechanisms was poorly understood. Here, we developed an ex vivo 3-dimensional angiogenic model using human fat, revealing that "appropriate" stiffness induces vascular maturation associated with upregulated APJ expression, whereas the overexpression of APJ promotes the formation of large vessels even in the absence of the "appropriate" stiffness.
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