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Anticoagulant Overdose With Paradoxical Thrombotic Risk.
Cureus
December 2024
Intensive Care Medicine, St George Hospital, Sydney, AUS.
We report a case of an unusual polypharmacy overdose including warfarin in a patient with a metallic heart valve, complicated by the history that he had ceased taking anticoagulation in the preceding few months, that placed him in an initial prothrombotic phase during his presentation. Our case highlights the importance of elucidating all relevant clinical details in a polypharmacy overdose, as clearly and rapidly as feasible, to enable appropriate management.
View Article and Find Full Text PDFBaclofen overdose with unique cardiovascular effects.
BMJ Case Rep
September 2024
Department of Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA
Case Presentation: A woman in her 70s was found unresponsive and brought to our hospital with respiratory distress, cardiomyopathy and volatile alternation between hypotension and hypertension. She was intubated and admitted to intensive care for supportive treatment of suspected baclofen overdose. She gradually recovered and was discharged 10 days after presentation.
View Article and Find Full Text PDFPreventing Pediatric Opioid Poisoning: Unusual Sources and Scenarios.
J Pediatr
December 2024
New Jersey Poison Information and Education System, Newark, NJ; Department of Emergency Medicine, Rutgers New Jersey Medical School, Newark, NJ.
This retrospective study analyzed 230 pediatric opioid exposures from a statewide poison control center over a 5-year period. Most exposures involved pharmaceutical opioids and children below 2-years-old. Narrative details were reviewed to identify uncommon sources of opioids involved in poisoning and highlight the need for tailored prevention strategies and guidance.
View Article and Find Full Text PDFExtrapyramidal Syndrome due to Aripiprazole Overdose in a Young Woman: An Unusual Case Report.
Case Rep Med
August 2024
Aripiprazole is an atypical antipsychotic medication indicated for the treatment of schizophrenia and bipolar disorders. The drug has been shown to exhibit acceptable efficacy and is often preferred as a first-line psychiatric treatment option owing to its lower incidence of adverse effects. While first-generation antipsychotics are associated with extrapyramidal syndrome (EPS), atypical antipsychotics such as aripiprazole are generally associated with a lower frequency of EPS.
View Article and Find Full Text PDFMassive lignocaine overdose while on veno-arterial extracorporeal membrane oxygenation (VA ECMO).
Toxicol Rep
June 2024
Westmead Hospital, Sydney, Australia.
We present the extraordinary circumstance of a female patient in her sixties who suffered a massive lignocaine overdose while undergoing treatment with Veno-Arterial Extracorporeal Membrane Oxygenation (VA ECMO) following an emergency coronary artery bypass graft (CABG). The patient was initially admitted to the Intensive Care Unit (ICU) due to unstable angina and a history of insulin-dependent type two diabetes mellitus, hypertension, hypercholesterolemia, carotid artery stenosis, and an extensive smoking history. Despite initial improvements following surgery, she experienced repeated episodes of nonsustained polymorphic ventricular tachycardia (VT) that were refractory to conventional antiarrhythmic medications.
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