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| http://dx.doi.org/10.18632/oncotarget.15131 | DOI Listing |
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Trazodone, dibenzoylmethane and tauroursodeoxycholic acid do not prevent motor dysfunction and neurodegeneration in Marinesco-Sjögren syndrome mice.
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Department of Neuroscience, Laboratory of Prion Neurobiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
There is no cure for Marinesco-Sjögren syndrome (MSS), a genetic multisystem disease linked to loss-of-function mutations in the SIL1 gene, encoding a BiP co-chaperone. Previously, we showed that the PERK kinase inhibitor GSK2606414 delays cerebellar Purkinje cell (PC) degeneration and the onset of ataxia in the woozy mouse model of MSS. However, GSK2606414 is toxic to the pancreas and does not completely rescue the woozy phenotype.
View Article and Find Full Text PDFPhonetic retuning to idiosyncrasies in word onsets: The interplay of lexical context and prediction.
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University of Massachusetts-Amherst, Department of Psychological and Brain Sciences.
Listeners can use both lexical context (i.e., lexical knowledge activated by the word itself) and lexical predictions based on the content of a preceding sentence to adjust their phonetic categories to speaker idiosyncrasies.
View Article and Find Full Text PDFEnhanced detection of Brain-Derived Neurotrophic Factor (BDNF) using a reduced graphene oxide field-effect transistor aptasensor.
Nanoscale
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James Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, UK.
Neurodegenerative diseases, characterized by the progressive deterioration of neuronal function and structure, pose significant global public health and economic challenges. Brain-Derived Neurotrophic Factor (BDNF), a key regulator of neuroplasticity and neuronal survival, has emerged as a critical biomarker for various neurodegenerative and psychiatric disorders, including Alzheimer's disease. Traditional diagnostic methods, such as Enzyme-Linked Immunosorbent Assay (ELISA) and electrochemiluminescence (ECL) assays, face limitations in terms of sensitivity, stability, reproducibility, and cost-effectiveness.
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Department of Cardiovascular Medicine, Sakakibara Heart Institute, Tokyo 183-0003, Japan.
For effective exercise prescription for patients with cardiovascular disease, it is important to determine the target heart rate at the level of the anaerobic threshold (AT-HR). The AT-HR is mainly determined by cardiopulmonary exercise testing (CPET). The aim of this study is to develop a machine learning (ML) model to predict the AT-HR solely from non-exercise clinical features.
View Article and Find Full Text PDFQuercetin can improve anesthesia induced neuroinflammation and cognitive dysfunction by regulating miR-138-5p/ LCN2.
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Department of Neurosurgery, Xijing Hospital, No. 127, Changle West Road, Xi'an, 710032, China.
Background: Anesthesia can lead to functional cognitive impairment, which can seriously affect postoperative recovery. To investigate the effect and mechanism of quercetin (Que) in anesthetized rats, the study provided a new therapeutic idea for the prevention of cognitive dysfunction caused by anesthesia.
Methods: Cognitively impaired rats were constructed using Isoflurane (ISO) anesthesia and treated with Que.
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