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Definition and diagnostic criteria of clinical obesity.
Lancet Diabetes Endocrinol
January 2025
Division of Diabetes & Nutritional Sciences, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, UK; Catholic University of the Sacred Heart, Rome, Italy; University Polyclinic Foundation Agostino Gemelli IRCCS, Rome, Italy.
Cortical windows for implant and cement removal during revision total elbow arthroplasty.
JSES Int
November 2024
Division of Hand and Upper-Extremity Surgery, Department of Orthopaedic Surgery, Geisinger Commonwealth School of Medicine, Geisinger MSKI, Danville, PA, USA.
Background: Revision total elbow arthroplasty (rTEA) remains a technically challenging procedure with potential for substantial morbidity. Cases involving excessively long cement mantles, removal of well-fixed implants or infected revisions requiring complete cement removal introduce additional technical challenges. Our purpose was to describe the outcomes, results, and complications associated with the use of cortical windows in rTEA.
View Article and Find Full Text PDFPlasma galectin-9 levels correlate with blood monocyte turnover and predict simian/human immunodeficiency virus disease progression.
Transl Med Commun
January 2024
Department of Anatomy, Physiology, & Cell Biology, School of Veterinary Medicine, and California National Primate Research Center, University of California, Davis, County Road 98 & Hutchison Drive, Davis, CA, USA.
Background: Late-stage human immunodeficiency virus (HIV) infection is typically characterized by low CD4 + T-cell count. We previously showed that profound changes in the monocyte turnover (MTO) rate in rhesus macaques infected by the simian immunodeficiency virus (SIV) outperforms declining CD4 + T-cell counts in predicting rapid health decline associated with progression to terminal disease. High MTO is associated with increased tissue macrophage death.
View Article and Find Full Text PDFCausal language and inferences in observational rotator cuff database studies published from 2013 to 2022.
J Orthop
July 2025
Department of Orthopaedic Surgery, Virginia Commonwealth University, 1250 E. Marshall Street, Richmond, VA, 23219, USA.
Background: The use of large multi-institutional databases in rotator cuff repair (RCR) research is expanding, but these studies are observational and cannot establish causation. This study examines the prevalence of causal language in clinical RCR database studies published from 2013 to 2022.
Methods: Administrative database and clinical registry studies on RCR published in eight orthopaedic journals from 2013 to 2022 were systematically identified and graded by two reviewers for the presence, absence, or inconsistent use of causal language in both the title/abstract and the full text.
PhiSiCal-Checkup: A Bayesian framework to validate amino acid conformations within experimental protein structures.
Proc Natl Acad Sci U S A
January 2025
Department of Data Science and Artificial Intelligence, Monash University, Clayton, VIC 3800, Australia.
As structural biology and drug discovery depend on high-quality protein structures, assessment tools are essential. We describe a new method for validating amino-acid conformations: "PhiSiCal ([Formula: see text]al) Checkup." Twenty new joint probability distributions in the form of statistical mixture models explain the empirical distributions of dihedral angles [Formula: see text] of canonical amino acids in experimental protein structures.
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