Movement disorders following heart surgery are very unusual. Post-pump chorea is mainly a pediatric complication of heart surgery, typically manifesting after a latent period of normality and is usually related with long extracorporeal circulation time and deep hypothermia. We report a 73-year-old woman, without risk factors predisposing to paroxysmal movement disorders, presenting acute choreoathetoid movements 5 days after aortic valvular replacement with normal extracorporeal circulation time and perioperative normothermia.
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http://dx.doi.org/10.1016/j.jclinane.2016.08.043 | DOI Listing |
Sheng Li Xue Bao
February 2025
Key Laboratory for Neuroregeneration, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China.
Currently, the incidence of Parkinson's disease (PD) is on the rise. More and more evidences suggest that mitochondrial dysfunction plays a crucial role in the etiology of PD, and dysfunction of mitochondrial complex I (MCI) is one of the most critical factors leading to mitochondrial dysfunction. On one hand, MCI dysfunction stimulates dopaminergic neurons to produce reactive oxygen species (ROS).
View Article and Find Full Text PDFSheng Li Xue Bao
February 2025
Department of Neurobiology, School of Basic Medical Sciences, School of Basic Medical Sciences, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
The study aimed to investigate the effect of the CD200R1 gene deletion on microglia activation and nigrostriatal dopamine neuron loss in the Parkinson's disease (PD) process. The CRISPR-Cas9 technology was applied to construct the CD200R1 mice. The primary microglia cells of wild-type and CD200R1 mice were cultured and treated with bacterial lipopolysaccharide (LPS).
View Article and Find Full Text PDFDisabil Rehabil
March 2025
Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
Purpose: To describe the process of developing an interactive home therapy technology and evaluate its usability with children.
Materials And Methods: Design thinking guided our technology development with knowledge holders. User- and theory-informed design needs were defined by empathizing with users through observation, interviews and literature review.
BMC Pharmacol Toxicol
March 2025
Department of Pharmacy, Peking University Third Hospital, No.49 North Garden Road, Haidian District, Beijing, 100191, China.
Background: Dopamine receptor agonists (DAs) are widely used as first-line therapeutic agents for Parkinson's disease. However, comparative clinical trials assessing their safety profiles are limited. This study aims to compare adverse event (AE) data across various DAs to inform personalized treatment strategies.
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