A case of a chronic lung berylliosis in a 20-year-old woman with a 20-weeks pregnancy is described. The diagnosis is established on the basis of morphological features: fibrosing alveolitis with numerous lympho-histiocytic granulomas containing conchoidal bodies and the lung tissue chemical analysis showing the presence of beryllium (2.71 X 10(-6) g/organ). Morphology of the lungs is described in detail.

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Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Health, Denver, Colorado, USA.

Background: Despite the utility of the beryllium lymphocyte proliferation test (BeLPT), distinguishing sarcoidosis, a disease of unknown etiology, from chronic beryllium disease (CBD), has long posed a diagnostic challenge. It is unclear if beryllium-exposed sarcoidosis cases (Be-exp-Sarc) are clinically distinct from CBD, or are misdiagnosed cases of CBD.

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J Occup Environ Med

March 2024

From the Division of Occupational and Environmental Medicine, Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI (H.T., L.W., K.D.R.); and Materion Brush, Inc, Elmore, OH (C.D.).

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