Benzodiazepine withdrawal-induced catatonia is a rare phenomenon in the adult population and has never been reported in a pediatric patient. We present a 9-year-old boy who exhibited catatonia symptoms following discontinuation of a midazolam infusion in the pediatric intensive care unit. The pediatric anesthesia acute pain team was consulted. When the patient's altered mental status could not otherwise be explained, benzodiazepine withdrawal-induced catatonia was considered. A dose of 2 mg intravenous lorazepam was given and the patient's symptoms dramatically improved within 5 minutes of administration. The patient was successfully treated with an oral diazepam taper.
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http://dx.doi.org/10.1213/XAA.0000000000000482 | DOI Listing |
Ann Clin Psychiatry
February 2023
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
In our brief literature review, we discuss the changes in the concept of catatonia as well as its various types and symptoms. We also succinctly review the possible symptoms of clozapine withdrawal. In addition, we analyze the main features of the very few published cases of clozapine withdrawal-induced catatonia and the relationship between neuroleptic malignant syndrome and the malignant subtype of catatonia.
View Article and Find Full Text PDFJAAD Case Rep
March 2021
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.
Ir Med J
May 2019
Sligo Leitrim Mental Health Services, Rehabilitation and Recovery, Sligo
Aim To describe an uncommon side effect of sudden withdrawal of Clozapine. Method This case describes the occurrence of catatonia following the sudden discontinuation of long term Clozapine therapy. Results Symptoms resolved with treatment with benzodiazepines and IV fluids.
View Article and Find Full Text PDFA A Case Rep
May 2017
From the Departments of *Anesthesiology; †Pharmacy: Clinical and Administrative Sciences; and ‡Pediatrics, Critical Care, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Benzodiazepine withdrawal-induced catatonia is a rare phenomenon in the adult population and has never been reported in a pediatric patient. We present a 9-year-old boy who exhibited catatonia symptoms following discontinuation of a midazolam infusion in the pediatric intensive care unit. The pediatric anesthesia acute pain team was consulted.
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