AI Article Synopsis
- A new retinal prosthesis, called OUReP™, uses photoelectric dye-coupled polyethylene film to generate light-evoked electric potentials that can stimulate neurons.
- In a study involving 10 rats with hereditary retinal dystrophy, these films were implanted under the retina, and visual responses were monitored over 8 weeks.
- Results showed that the amplitude of visual evoked potentials was significantly higher in rats with dye-coupled film implants compared to those with plain films, indicating better stimulation from the OUReP™.
Article Abstract
Photoelectric dye-coupled polyethylene film, designated Okayama University type-retinal prosthesis or OUReP™, generates light-evoked surface electric potentials and stimulates neurons. The dye-coupled films or plain films were implanted subretinally in both eyes of 10 Royal College of Surgeons rats with hereditary retinal dystrophy at the age of 6 weeks. Visual evoked potentials in response to monocular flashing light stimuli were recorded from cranially-fixed electrodes, 4 weeks and 8 weeks after the implantation. After the recording, subretinal film implantation was confirmed histologically in 7 eyes with dye-coupled films and 7 eyes with plain films. The recordings from these 7 eyes in each group were used for statistical analysis. The amplitudes of visual evoked potentials in the consecutive time points from 125 to 250 ms after flash were significantly larger in the 7 eyes with dye-coupled film implantation, compared to the 7 eyes with plain film implantation at 8 weeks after the implantation (P < 0.05, repeated-measure ANOVA). The photoelectric dye-coupled polyethylene film, as retinal prosthesis, gave rise to visual evoked potential in response to flashing light.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446846 | PMC |
| http://dx.doi.org/10.1007/s10047-016-0943-4 | DOI Listing |
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