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Efficacy and Safety of Vildagliptin as an Add-On Therapy in Inadequately Controlled Type 2 Diabetes Patients Treated With Basal Insulin. | LitMetric

AI Article Synopsis

  • The study aimed to evaluate how effective and safe vildagliptin is as an additional treatment for patients with type 2 diabetes who are not adequately controlled with basal insulin.
  • Twenty-four patients were randomly divided into two groups: one received vildagliptin (100 mg/day) for six months, while the other did not receive additional medication.
  • Results showed that vildagliptin significantly reduced hemoglobin A1c levels compared to the control group and increased another marker, with minimal reports of hypoglycemia in both groups.

Article Abstract

Background: The aim of this study was to investigate the efficacy and safety of vildagliptin as an add-on therapy for patients with type 2 diabetes mellitus inadequately controlled with basal insulin.

Methods: Twenty-four patients treated with basal insulin and oral anti-diabetes drugs were randomly allocated into two groups: the control group (did not receive any add-on drugs) and vildagliptin group (received vildagliptin 100 mg/day for 6 months). The primary outcome was changes in hemoglobin A1c (HbA1c) from baseline to end of study.

Results: Treatment with vildagliptin significantly reduced HbA1c from 8.1±0.7% at baseline to 7.1±0.7% (P < 0.01), while there was no significant change of HbA1c in the control group. Vildagliptin group showed significant reduction of HbA1c compared with control group (-1.0±0.3% vs. 0.2±0.8%, P < 0.01). In addition, vildagliptin group showed a significant increase in 1,5-anhydroglucitol compared with the control group (4.5 ± 3.4 vs. 0.5 ± 4.1 μg/mL, P < 0.05). Mild hypoglycemia was reported in one patient of the vildagliptin group and two patients of the control group.

Conclusion: Vildagliptin improved glycemic control without increasing hypoglycemia in Japanese type 2 diabetes inadequately controlled with basal insulin treatment and other oral anti-diabetes drugs. This study was registered with UMIN (University Hospital Medical Information Network ID#000010849).

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289138PMC
http://dx.doi.org/10.14740/jocmr2874wDOI Listing

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