AI Article Synopsis
- Long non-coding RNAs (lncRNAs) like CRNDE play important roles in biological processes and are implicated in tumor development, particularly in hepatoblastoma.
- The study finds that CRNDE is significantly elevated in hepatoblastoma tissues and cell lines, and its knockdown leads to reduced tumor growth and angiogenesis.
- CRNDE's effects on proliferation and angiogenesis are linked to the regulation of the mTOR signaling pathway, suggesting its potential as a diagnostic marker and therapeutic target for hepatoblastoma.
Article Abstract
Long non-coding RNAs (lncRNAs) are involved in many biological processes, such as angiogenesis, invasion, cell proliferation, and apoptosis. They have emerged as key players in the pathology of several tumors, including hepatoblastoma. In this study, we elucidate the biological and clinical significance of CRNDE up-regulation in hepatoblastoma. CRNDE is significantly up-regulated in human hepatoblastoma specimens and metastatic hepatoblastoma cell lines. CRNDE knockdown reduces tumor growth and tumor angiogenesis in vivo, and decreases hepatoblastoma cell viability, proliferation, and angiogenic effect in vitro. Mechanistic studies show that CRNDE knockdown plays its anti-proliferation and anti-angiogenesis role via regulating mammalian target of rapamycin (mTOR) signaling. Taken together, this study reveals a crucial role of CRNDE in the pathology of hepatoblastoma. CRNDE may serve as a promising diagnostic marker and therapeutic target for hepatoblastoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522051 | PMC |
| http://dx.doi.org/10.18632/oncotarget.14992 | DOI Listing |
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