The objective of this review is to identify the effectiveness of expanded cardiac rehabilitation (CR) in patients diagnosed with coronary heart disease (CHD). Specifically, the review question is: What is the effectiveness of expanded CR compared to standard CR in adult patients diagnosed with CHD? Effectiveness will be assessed by the effect on mortality and readmissions due to all causes or any cardiac event, systolic blood pressure, cholesterol levels and adherence to recommendations in secondary prevention guidelines.
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http://dx.doi.org/10.11124/JBISRIR-2016-003265 | DOI Listing |
Commun Biol
January 2025
San Raffaele Diabetes Research Institute, IRCCS Ospedale San Raffaele Milan, Milan, Italy.
Tregs for adoptive therapy are traditionally expanded ex vivo using high doses of IL-2. However, the final Treg product has limited survival once infused in patients, potentially affecting therapeutic effectiveness. Here, we tested a novel expansion protocol in which highly purified naïve Tregs were expanded with a combination of IL-7 and IL-15, in the absence of IL-2.
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January 2025
Fugu Energy Investment Group Shagoucha Mining Co., Ltd.,, Fugu, 719000, China.
The formation and development of plastic zone in the surrounding rock is the essence of large deformation damage to the surrounding rock in deep, highly stressed roadway. The -850 m roadway of the Qujiang mine is laid flat longitudinally under the 805 working face and coal pillar, and under the influence of the mining movement of the upper working face and the pre-stressing pressure of the coal pillar, the periphery of the roadway is no longer a pure non-uniform stress field, but a non-uniform stress field with both vertical and horizontal dynamic pressure. Based on the Hoek-Brown strength criterion, the unified strength theory is modified and the nonlinear unified strength theory of rock is established by comprehensively considering the intermediate principal stress, rock properties and rock structure.
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January 2025
College of Computer and Mathematics, Central South University of Forestry and Technology, Changsha, 410004, China.
Ormosia microphylla is a nationally prioritized wild plant in China but effects of likely future climate change have been poorly studied. Here distribution data of O. microphylla and environmental data with an optimized MaxEnt maximum entropy model were used to predict potentially suitable areas under current and future climate scenarios.
View Article and Find Full Text PDFClin Lymphoma Myeloma Leuk
December 2024
Incyte Corporation, Wilmington, DE.
Myelofibrosis (MF) is a rare myeloproliferative neoplasm characterized by progressive bone marrow fibrosis and splenomegaly. Ruxolitinib is the standard-of-care first-line treatment option for MF. This review summarizes real-world effectiveness and safety of ruxolitinib in more than 4500 patients with MF from real-world settings, including expanded-access and phase 4 trials, as well as registry, postmarketing, and retrospective studies in the 10 years since regulatory approval.
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January 2025
Clinical Pediatrics Unit, Department of Women's and Children's Health, Karolinska Institutet, 17165 Stockholm, Sweden; Department of Immunology and Inflammation, Imperial College London, London W12 EH7, UK; Medical Research Council, Laboratory of Medical Sciences, Imperial College Hammersmith Campus, London, UK; Pediatric Rheumatology, Astrid Lindgren Children's Hospital, Karolinska University Hospital, 17176 Stockholm, Sweden. Electronic address:
Cancer is the leading cause of death from disease in children. Survival depends not only on surgery, cytostatic drugs, and radiation but also on systemic immune responses. Factors influencing these immune responses in children of different ages and tumor types are unknown.
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