The aim of this study was to evaluate the antitumor effect and toxicity of a single course of Peptichemio at high dose (450 mg/sq m) given to children with neuroblastoma resistant to first line treatment or at relapse. A total of 28 children were treated. Seven children showed partial response, 4 minor response, 8 had stable disease, and in 8 the tumor progressed. The principal toxic effect was myelosuppression. Hemorrhagic enteritis with liver failure and toxic death occurred in 1 patient. High dose Peptichemio can be administered with tolerable toxicity, inducing tumor regression in one third of previously treated patients.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
high dose
12
dose peptichemio
8
peptichemio pretreated
4
pretreated neuroblastoma
4
neuroblastoma aim
4
aim study
4
study evaluate
4
evaluate antitumor
4
antitumor toxicity
4
toxicity single
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!