AI Article Synopsis
- The study evaluates the effectiveness of intralesional rituximab in treating indolent primary cutaneous B-cell lymphoma (PCBL), finding that 72% of patients showed a significant clinical response.
- Many patients experienced flu-like symptoms post-injection, which correlated with better treatment outcomes, suggesting these side effects could indicate a favorable response.
- Overall, patients expressed high satisfaction with rituximab therapy, ranking it more favorable compared to traditional treatments like excision and radiotherapy.
Article Abstract
Background And Objectives: Intralesional injection of anti-CD20 antibody (rituximab) has been described as effective therapeutic option for patients with indolent primary cutaneous B-cell lymphoma (PCBL). To date, no parameters that reproducibly predict favorable clinical outcome of this treatment have been identified. The study aims to evaluate the clinical response and adverse effects as well as patients' self-perception of intralesional injection of anti-CD20 antibody for treatment of indolent PCBL compared to other treatment modalities.
Patients And Methods: Eleven patients with PCBL, namely primary cutaneous follicle center lymphoma (n = 9) and primary cutaneous marginal zone lymphoma (n = 2), treated with intralesional anti-CD20 antibody were retrospectively evaluated for response rate and adverse events as well as their self-perception of anti-CD20 antibody therapy and other therapies of PCBL.
Results: Patients treated with intralesional anti-CD20 antibody for PCBL showed complete response or partial response in 45 % or 27 % of patients, respectively. Particularly, patients with marked flu-like symptoms after intralesional injection of rituximab responded very well to rituximab. The majority of patients considered rituximab as best therapy compared to other therapies such as excision or radiotherapy.
Conclusions: Intralesional rituximab is an effective therapy with high patient satisfaction. Strong therapy induced side effects of fever, chills and headache after administration of rituximab might be used as indicator for favorable response.
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| http://dx.doi.org/10.1111/ddg.13188 | DOI Listing |
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