AI Article Synopsis
- The angiotensin-converting enzyme (ACE) regulates blood vessel function by breaking down angiotensin I and bradykinin, which influences smooth muscle growth and vascular tone.
- Research has examined the impact of the I/D polymorphism in ACE on coronary heart disease (CHD) risk, especially focusing on patients under 55 years old.
- Findings indicate that individuals with the DD genotype of the ACE polymorphism have a 2.3 times greater risk of developing CHD compared to healthy controls.
Article Abstract
The angiotensin-converting enzyme (ACE) plays by degradation of angiotensin I and bradykinin, an important role in modulations of smooth muscle proliferation and vascular tone. Typical plasma levels of ACE accompany the I/D polymorphism; however, a controversy exists as to whether the DD genotype of the ACE polymorphism affects the risk for the development of coronary heart disease (CHD). We compared the I/D polymorphism in 171 Slovenian CHD patients that were younger man 55 years with 134 healthy control individuals. The DD genotype is associated with a 2.3 - fold increase in the risk for CHD.
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| http://dx.doi.org/10.1007/s004240000084 | DOI Listing |
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