AI Article Synopsis
- A new method for N-formylation using ethyl formate and various amines has been created, leveraging bio-catalysis.
- This process is simple and efficient, operating under mild conditions while allowing for a wide range of amines and the reuse of lipase.
- It is also scalable, producing high yields even in larger quantities.
Article Abstract
A bio-catalyzed N-formylation reaction of different amines has been developed using ethyl formate as a formylating agent. This protocol provides a facile and convenient strategy featuring mild reaction conditions, high efficacy, a broad substrate scope and recyclability of lipase. This method also works on a large scale in high yield.
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| http://dx.doi.org/10.1039/c6cc07679c | DOI Listing |
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