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| http://dx.doi.org/10.1016/j.jcmgh.2016.06.001 | DOI Listing |
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Electron transfer in polysaccharide monooxygenase catalysis.
Proc Natl Acad Sci U S A
January 2025
California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720.
Polysaccharide monooxygenase (PMO) catalysis involves the chemically difficult hydroxylation of unactivated C-H bonds in carbohydrates. The reaction requires reducing equivalents and will utilize either oxygen or hydrogen peroxide as a cosubstrate. Two key mechanistic questions are addressed here: 1) How does the enzyme regulate the timely and tightly controlled electron delivery to the mononuclear copper active site, especially when bound substrate occludes the active site? and 2) How does this electron delivery differ when utilizing oxygen or hydrogen peroxide as a cosubstrate? Using a computational approach, potential paths of electron transfer (ET) to the active site copper ion were identified in a representative AA9 family PMO from (PMO9E).
View Article and Find Full Text PDFThe journey to diagnosis of wild-type transthyretin-mediated (ATTRwt) amyloidosis: a path with multisystem involvement.
Orphanet J Rare Dis
November 2024
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA.
Background: Wild-type and hereditary transthyretin-mediated amyloidosis (ATTRwt and ATTRv amyloidosis, respectively) are progressive, fatal diseases with a broad range of clinical presentations and multisystem effects. Despite having a higher prevalence, ATTRwt amyloidosis is less well characterized due to its non-hereditary nature, and its relatively poorer disease awareness delays diagnosis. Understanding of its natural history has evolved in recent years, but this is largely based on physician-collected data rather than patients' reports of their own experiences.
View Article and Find Full Text PDFGraphene oxide in low concentrations can change mitochondrial potential, autophagy, and apoptosis paths in two strains of invertebrates with different life strategies.
Biochem Biophys Res Commun
December 2024
Institute of Biology, Biotechnology and Environmental Protection, University of Silesia in Katowice, Poland.
Nanoparticles, like graphene oxide (GO), are particles with unique physiochemical properties that enable their wide application in various areas of life. The effects of GO on individual cell organelles like mitochondria and the effects of interactions are worth investigating, as they can activate multiple cellular processes, such as autophagy or apoptosis. Mitochondrial injury plays an essential role in the majority of cell death routines.
View Article and Find Full Text PDFForce-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth.
Nat Commun
October 2024
KU Leuven, Department of Mechanical Engineering, Biomechanics section, Leuven, Belgium.
Article Synopsis
- - The study investigates how cellular interactions, driven by force, contribute to cancer cell invasion, particularly in the context of cerebral cavernous malformations (CCM), which are characterized by abnormal blood vessels.
- - Researchers used an in-vitro model to demonstrate that endothelial cells lacking the CCM2 protein help recruit normal (wild-type) endothelial cells through mechanical forces and changes in the surrounding extracellular matrix, facilitating lesion growth.
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Going or Returning to Nature? Wild Vegetable Uses in the Foraging-Centered Restaurants of Lombardy, Northern Italy.
Plants (Basel)
August 2024
University of Gastronomic Sciences, Piazza Vittorio Emanuele II 9, 12042 Pollenzo, Italy.
Wild vegetables (WVs) have been an essential source of human nutrition since ancient times. Foraging is a millennia-old practice that has gained more attention recently and is becoming fashionable, especially in restaurants in urban areas, as they attract customers who see WVs as an innovative sensory element and specialty food. Some cooks have used very few WVs for decades, but most chefs have only recently introduced them in their modern restaurants.
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