AI Article Synopsis
- - The study investigates the chemical composition and bioactivity of Ramaria largentii, an edible orange coral mushroom, revealing a total phenolic content of 42.33 mg GAE/g and the presence of protocatechuic and vanillic acids.
- - The hydromethanolic extract of the mushroom demonstrated effective antioxidant properties, showing strong free radical scavenging and reducing capacities with EC values of 64.3 and 61.54 μg/mL, respectively.
- - Importantly, the extract showed no genotoxic effects in normal Vero cells and provided significant protection against DNA damage caused by hydroxyl radicals, indicating its potential health benefits.
Article Abstract
Ramaria largentii Marr & D. E. Stuntz (orange coral mushroom) is a wild edible mushroom whose chemical composition and bioactivity have not been investigated. Herein, we present a study on the phenolic constituents, antioxidant and antigenotoxic effects of a hydromethanolic extract of the fruiting bodies. Total phenolic content, estimated by Folin-Ciocalteu assay, was found to be 42.33 ± 0.18 mg GAE/g. Protocatechuic and vanillic acids were detected by HPLC-DAD-ESI-MS. The extract showed good free radical scavenging and reducing capacities (EC = 64.3 ± 0.2 and 61.54 ± 0.46 μg/mL, respectively). In normal Vero cells, the extract (100, 200 and 300 μg/mL) showed no genotoxic potential and moreover, almost completely protected DNA against HO-induced damage (2.09-7.91% tail DNA) (24 and 48 h pre-treatment). Taken together, the results of our study show that Ramaria largentii extract is devoid of genotoxicity and has a remarkable DNA protective activity against HO-induced damage.
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| http://dx.doi.org/10.1016/j.fct.2017.02.006 | DOI Listing |
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Antioxidant and antigenotoxic potential of Ramaria largentii Marr & D. E. Stuntz, a wild edible mushroom collected from Northeast Romania.
Food Chem Toxicol
October 2017
Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, Universitatii Str. 16, 700115 Iasi, Romania. Electronic address:
Article Synopsis
- - The study investigates the chemical composition and bioactivity of Ramaria largentii, an edible orange coral mushroom, revealing a total phenolic content of 42.33 mg GAE/g and the presence of protocatechuic and vanillic acids.
- - The hydromethanolic extract of the mushroom demonstrated effective antioxidant properties, showing strong free radical scavenging and reducing capacities with EC values of 64.3 and 61.54 μg/mL, respectively.
- - Importantly, the extract showed no genotoxic effects in normal Vero cells and provided significant protection against DNA damage caused by hydroxyl radicals, indicating its potential health benefits.
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