Data from a family study of psychiatric disorders showed higher rates of major affective disorders, eating disorders, and alcoholism in first-degree relatives of 40 bulimic probands than in first-degree relatives of 24 control subjects. More importantly, the data showed higher rates of major affective disorders in relatives of bulimic probands who themselves had no history of major affective disorders than in relatives of control subjects. This significant finding indicates a familial relationship between bulimia nervosa and major affective disorders, which suggests the possibility of a common diathesis.
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Aim: The study aim was to investigate the effect of the 2024 Noto Peninsula earthquake on regular psychiatric outpatient check-ups at Kanazawa Medical University Hospital, Japan.
Methods: We retrospectively collected electronic medical records from January 4 to January 17, 2024, and analyzed data from 656 patients. was used to analyze the association between adherence to scheduled visits and related factors, and the association between inability to attend scheduled visits and self-reported earthquake-related reasons among 84 nonadherent patients.
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Department of Physiology, RUHS College of Medical Sciences, India.
Background: Previous research has shown that Major Depressive Disorder (MDD) is accompanied by severe impairments in cognitive and autonomic processes, which may linger even when mood symptoms recover. This study aimed to analyse the relationship between depression severity, as measured by the Hamilton Depression Rating Scale (HAM-D), and how it affects heart rate variability (HRV) and cognitive function in patients with Major Depressive Disorder (MDD).
Methodology: The cross-sectional study was conducted at RUHS College of Medical Sciences and Associated Hospitals, Jaipur, from July 2022 to January 2023 on 90 subjects having major depressive disorder (MDD) of either sex in the 20-40 age group using the Hamilton score for depression (HAM D), Heart Rate Variability (HRV) measurements, and a battery of cognitive tests.
Age-related p53 SUMOylation accelerates senescence and tau pathology in Alzheimer's disease.
Cell Death Differ
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Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Aging is a major risk factor for Alzheimer's disease (AD). With the prevalence of AD increased, a mechanistic linkage between aging and the pathogenesis of AD needs to be further addressed. Here, we report that a small ubiquitin-related modifier (SUMO) modification of p53 is implicated in the process which remarkably increased in AD patient's brain.
View Article and Find Full Text PDFLongitudinal Symptom Burden and Pharmacologic Management of Catatonia in Autism With Intellectual Disability: An Observational Study.
Autism Res
January 2025
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Catatonia is a highly morbid psychomotor and affective disorder, which can affect autistic individuals with and without intellectual disability. Catatonic symptoms are treatable with pharmacotherapy and electroconvulsive therapy, but the longitudinal effectiveness of these treatments in autistic individuals has not been described. We conducted a prospective observational cohort study of patients with autism and co-morbid catatonia who received outpatient care in a specialized outpatient clinic from July 1, 2021 to May 31, 2024.
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