We treated three patients under 20 years of age who had idiopathic premacular gliosis, a disorder found primarily in patients older than 50 years of age. Initial visual acuity ranged from 20/20 to 20/50, remained unchanged in one patient, improved in one patient, and decreased in one patient. Final visual acuity ranged from 20/15 to 20/500 with an average follow-up of 60 months (range, ten to 102 months). Included in this series is a 6-year-old boy with idiopathic premacular gliosis. Children and adolescents with idiopathic premacular gliosis may develop progressive visual loss to a level where vitrectomy should be considered.
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http://dx.doi.org/10.1016/0002-9394(89)90437-6 | DOI Listing |
Graefes Arch Clin Exp Ophthalmol
March 2022
Department of Ophthalmology, Ludwig-Maximilians-University, Vitreoretinal Pathology Unit, Mathildenstrasse 8, 80336, Munich, Germany.
Purpose: To describe characteristics of the vitreomacular interface (VMI) in traumatic macular holes (TMH) compared to idiopathic macular holes (IMH) using immunofluorescence and electron microscopy, and to correlate with clinical data.
Methods: For immunocytochemical and ultrastructural analyses, premacular tissue with internal limiting membrane (ILM) and epiretinal membrane (ERM) was harvested during vitrectomy from 5 eyes with TMH and 5 eyes with IMH. All specimens were processed as flat mounts for phase-contrast microscopy, interference and fluorescence microscopy, and transmission electron microscopy (TEM).
Am J Ophthalmol
September 2020
Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
Purpose: To compare characteristics of the vitreomacular interface (VMI) in myopic foveoschisis (mFS) and idiopathic epiretinal membrane foveoschisis (iERM-FS), and to correlate with optical coherence tomography and clinical data.
Design: Clinicopathologic study.
Methods: Epiretinal membrane and internal limiting membrane (ILM) specimens were removed from eyes with mFS (5 eyes) and iERM-FS (5 eyes).
Curr Eye Res
November 2020
Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
: To describe the presence of neurotrophic growth factors and histopathologic characteristics of internal limiting membrane (ILM) specimens obtained from large idiopathic full-thickness macular holes (FTMH). : In 24 eyes of 24 patients with FTMH of diameter >400 µm, ILM specimens were harvested directly at the edge surrounding the macular hole during vitrectomy with peeling. We performed interference and phase contrast microscopy of flat mounts followed by immunostaining and transmission electron microscopy.
View Article and Find Full Text PDFPLoS One
November 2019
Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan.
We previously reported on the elevated intravitreal activities of tryptase and chymase in association with idiopathic epiretinal membrane (ERM) and idiopathic macular hole (MH). In this present study, we investigated the potential intraocular production of these serine proteases, and measured and compared tryptase and chymase activities in the vitreous body and serum in ERM, MH, proliferative diabetic retinopathy (PDR), and rhegmatogenous retinal detachment (RRD) patients. In addition, nuclear staining with hematoxylin and eosin (H&E) and mast-cell staining with toluidine blue were performed on samples of the vitreous core and bursa premacularis (BPM) of MH.
View Article and Find Full Text PDFCurr Eye Res
March 2019
a Department of Ophthalmology , Ludwig-Maximilians-University, Munich , Germany.
Purpose: To describe and compare characteristics of premacular membranes in idiopathic macular pucker (iMP) and proliferative vitreoretinopathy (PVR) using immunofluorescence and transmission electron microscopy.
Materials And Methods: For immunocytochemical and ultrastructural analyses, premacular membranes were harvested during vitrectomy from 16 eyes with iMP and 12 eyes with PVR. All specimens were processed as flat mounts for phase-contrast and fluorescence microscopy.
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