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The Use of Maximum-Intensity Projections and Deep Learning Adds Value to the Fully Automatic Segmentation of Lesions Avid for [F]FDG and [Ga]Ga-PSMA in PET/CT.
J Nucl Med
March 2025
Champalimaud Clinical Centre, Champalimaud Foundation, Lisbon, Portugal; and.
This study investigated the added value of using maximum-intensity projection (MIP) images for fully automatic segmentation of lesions using deep learning (DL) in [F]FDG and [Ga]Ga-prostate-specific membrane antigen (PSMA) PET/CT scans. We used 489 staging [F]FDG PET/CT scans from patients diagnosed with melanoma, lymphoma, or lung cancer (391 scans for training and 98 for internal testing). As an external test set, 117 staging [F]FDG PET/CT scans from lymphoma patients (another center, 2 scanners) were used.
View Article and Find Full Text PDFAssociation Between Body Fat Percentage and Urinary Flow Rate in US Adults: Analysis of the National Health and Nutrition Examination Survey 2011-2018.
Br J Nutr
March 2025
The Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospital),Department of Urology,523000 No.3 South Wanlu Road, Xingu Yong, Wanjiang District, Dongguan City, Guangdong Province, China.
To assess the relationship between total body fat percentage(TBFP), trunk fat percentage(TFP), and urinary flow rate(UFR).We stratified by age and sex and hypothesize that TBFP and TFP are negatively associated with UFR across all groups.The study utilized data from the National Health and Nutrition Examination Survey (NHANES), which includes a series of nationally representative cross-sectional surveys.
View Article and Find Full Text PDFComparison of [Ga]Ga-Fibroblast Activation Protein Inhibitor-04 and [F]FDG PET Imaging for Solitary Fibrous Tumor and Preliminary Application of FAP-Targeted Radiopharmaceutical Therapy.
J Nucl Med
March 2025
Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
Solitary fibrous tumor (SFT) is a rare sarcoma of mesenchymal origin. Although generally benign, SFTs carry the risk of recurrence and metastasis, with limited effective treatment options. The aims of this study are to compare the performance of fibroblast activation protein inhibitor (FAPI), [Ga]Ga-DOTA-FAPI-04 (denoted as [Ga]Ga-FAPI-04), and conventional [F]FDG PET/CT in patients with recurrent or metastatic SFTs head to head and to preliminarily explore the value of FAP-targeted radiopharmaceutical therapy with Lu for SFT patients.
View Article and Find Full Text PDFTotal-Body Parametric Imaging Using Relative Patlak Plot.
J Nucl Med
February 2025
Department of Radiology, University of California Davis Medical Center, Sacramento, California; and.
The standard Patlak plot, a simple yet efficient model, is widely used to describe irreversible tracer kinetics for dynamic PET imaging. Its widespread application to whole-body parametric imaging remains constrained because of the need for a full-time-course input function (e.g.
View Article and Find Full Text PDF3D: three-dimensional positron imaging, a novel total-body PET scanner using xenon-doped liquid argon scintillator.
Phys Med Biol
March 2025
AstroCeNT, Nicolaus Copernicus Astronomical Center of the Polish Academy of Sciences, Warsaw, Poland.
This paper introduces a novel PET imaging methodology called 3-dimensional positron imaging (3D), which integrates total-body coverage, time-of-flight (TOF) technology, ultra-low dose imaging capabilities, and ultra-fast readout electronics inspired by emerging technology from the DarkSide collaboration.The study evaluates the performance of 3Dusing Monte Carlo simulations based on NEMA NU 2-2018 protocols. The methodology employs a homogenous, monolithic scintillator composed of liquid argon (LAr) doped with xenon (Xe) with silicon photomultipliers (SiPMs) operating at cryogenic temperatures.
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